High-Risk Acute Myeloid Leukemia: A Pediatric Prospective
Publication
, Journal Article
Cacace, F; Iula, R; De Novellis, D; Caprioli, V; D’amico, MR; De Simone, G; Cuccurullo, R; Wierda, WG; Mahadeo, KM; Menna, G; Tambaro, FP
Published in: Biomedicines
June 1, 2022
Pediatric acute myeloid leukemia is a clonal disorder characterized by malignant trans-formation of the hematopoietic stem cell. The incidence and the outcome remain inferior when compared to pediatric ALL, although prognosis has improved in the last decades, with 80% overall survival rate reported in some studies. The standard therapeutic approach is a combined cytarabine and anthracycline-based regimen followed by consolidation with allogeneic stem cell transplantation (allo-SCT) for high-risk AML and allo-SCT for non-high-risk patients only in second complete remission after relapse. In the last decade, several drugs have been used in clinical trials to improve outcomes in pediatric AML treatment.
Duke Scholars
Published In
Biomedicines
DOI
EISSN
2227-9059
Publication Date
June 1, 2022
Volume
10
Issue
6
Related Subject Headings
- 3404 Medicinal and biomolecular chemistry
- 3214 Pharmacology and pharmaceutical sciences
- 3101 Biochemistry and cell biology
Citation
APA
Chicago
ICMJE
MLA
NLM
Cacace, F., Iula, R., De Novellis, D., Caprioli, V., D’amico, M. R., De Simone, G., … Tambaro, F. P. (2022). High-Risk Acute Myeloid Leukemia: A Pediatric Prospective. Biomedicines, 10(6). https://doi.org/10.3390/biomedicines10061405
Cacace, F., R. Iula, D. De Novellis, V. Caprioli, M. R. D’amico, G. De Simone, R. Cuccurullo, et al. “High-Risk Acute Myeloid Leukemia: A Pediatric Prospective.” Biomedicines 10, no. 6 (June 1, 2022). https://doi.org/10.3390/biomedicines10061405.
Cacace F, Iula R, De Novellis D, Caprioli V, D’amico MR, De Simone G, et al. High-Risk Acute Myeloid Leukemia: A Pediatric Prospective. Biomedicines. 2022 Jun 1;10(6).
Cacace, F., et al. “High-Risk Acute Myeloid Leukemia: A Pediatric Prospective.” Biomedicines, vol. 10, no. 6, June 2022. Scopus, doi:10.3390/biomedicines10061405.
Cacace F, Iula R, De Novellis D, Caprioli V, D’amico MR, De Simone G, Cuccurullo R, Wierda WG, Mahadeo KM, Menna G, Tambaro FP. High-Risk Acute Myeloid Leukemia: A Pediatric Prospective. Biomedicines. 2022 Jun 1;10(6).
Published In
Biomedicines
DOI
EISSN
2227-9059
Publication Date
June 1, 2022
Volume
10
Issue
6
Related Subject Headings
- 3404 Medicinal and biomolecular chemistry
- 3214 Pharmacology and pharmaceutical sciences
- 3101 Biochemistry and cell biology