Global translational induction during NLR-mediated immunity in plants is dynamically regulated by CDC123, an ATP-sensitive protein.
The recognition of pathogen effectors by their cognate nucleotide-binding leucine-rich repeat (NLR) receptors activates effector-triggered immunity (ETI) in plants. ETI is associated with correlated transcriptional and translational reprogramming and subsequent death of infected cells. Whether ETI-associated translation is actively regulated or passively driven by transcriptional dynamics remains unknown. In a genetic screen using a translational reporter, we identified CDC123, an ATP-grasp protein, as a key activator of ETI-associated translation and defense. During ETI, an increase in ATP concentration facilitates CDC123-mediated assembly of the eukaryotic translation initiation factor 2 (eIF2) complex. Because ATP is required for the activation of NLRs as well as the CDC123 function, we uncovered a possible mechanism by which the defense translatome is coordinately induced during NLR-mediated immunity. The conservation of the CDC123-mediated eIF2 assembly suggests its possible role in NLR-mediated immunity beyond plants.
Duke Scholars
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Related Subject Headings
- Proteins
- Protein Domains
- Plants
- Plant Immunity
- Plant Diseases
- NLR Proteins
- Immunology
- Eukaryotic Initiation Factor-2
- Adenosine Triphosphate
- 3207 Medical microbiology
Citation
Published In
DOI
EISSN
ISSN
Publication Date
Volume
Issue
Start / End Page
Related Subject Headings
- Proteins
- Protein Domains
- Plants
- Plant Immunity
- Plant Diseases
- NLR Proteins
- Immunology
- Eukaryotic Initiation Factor-2
- Adenosine Triphosphate
- 3207 Medical microbiology