Skip to main content
Journal cover image

Artificial intelligence and high-dimensional technologies in the theragnosis of systemic lupus erythematosus.

Publication ,  Journal Article
Yaung, KN; Yeo, JG; Kumar, P; Wasser, M; Chew, M; Ravelli, A; Law, AHN; Arkachaisri, T; Martini, A; Pisetsky, DS; Albani, S
Published in: Lancet Rheumatol
March 2023

Systemic lupus erythematosus is a complex, systemic autoimmune disease characterised by immune dysregulation. Pathogenesis is multifactorial, contributing to clinical heterogeneity and posing challenges for diagnosis and treatment. Although strides in treatment options have been made in the past 15 years, with the US Food and Drug Administration approval of belimumab in 2011, there are still many patients who have inadequate responses to therapy. A better understanding of underlying disease mechanisms with a holistic and multiparametric approach is required to improve clinical assessment and treatment. This Review discusses the evolution of genomics, epigenomics, transcriptomics, and proteomics in the study of systemic lupus erythematosus and ways to amalgamate these silos of data with a systems-based approach while also discussing ways to strengthen the overall process. These mechanistic insights will facilitate the discovery of functionally relevant biomarkers to guide rational therapeutic selection to improve patient outcomes.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Lancet Rheumatol

DOI

EISSN

2665-9913

Publication Date

March 2023

Volume

5

Issue

3

Start / End Page

e151 / e165

Location

England

Related Subject Headings

  • United States
  • Lupus Erythematosus, Systemic
  • Humans
  • Genomics
  • Gene Expression Profiling
  • Epigenomics
  • Artificial Intelligence
  • 3202 Clinical sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Yaung, K. N., Yeo, J. G., Kumar, P., Wasser, M., Chew, M., Ravelli, A., … Albani, S. (2023). Artificial intelligence and high-dimensional technologies in the theragnosis of systemic lupus erythematosus. Lancet Rheumatol, 5(3), e151–e165. https://doi.org/10.1016/S2665-9913(23)00010-3
Yaung, Katherine Nay, Joo Guan Yeo, Pavanish Kumar, Martin Wasser, Marvin Chew, Angelo Ravelli, Annie Hui Nee Law, et al. “Artificial intelligence and high-dimensional technologies in the theragnosis of systemic lupus erythematosus.Lancet Rheumatol 5, no. 3 (March 2023): e151–65. https://doi.org/10.1016/S2665-9913(23)00010-3.
Yaung KN, Yeo JG, Kumar P, Wasser M, Chew M, Ravelli A, et al. Artificial intelligence and high-dimensional technologies in the theragnosis of systemic lupus erythematosus. Lancet Rheumatol. 2023 Mar;5(3):e151–65.
Yaung, Katherine Nay, et al. “Artificial intelligence and high-dimensional technologies in the theragnosis of systemic lupus erythematosus.Lancet Rheumatol, vol. 5, no. 3, Mar. 2023, pp. e151–65. Pubmed, doi:10.1016/S2665-9913(23)00010-3.
Yaung KN, Yeo JG, Kumar P, Wasser M, Chew M, Ravelli A, Law AHN, Arkachaisri T, Martini A, Pisetsky DS, Albani S. Artificial intelligence and high-dimensional technologies in the theragnosis of systemic lupus erythematosus. Lancet Rheumatol. 2023 Mar;5(3):e151–e165.
Journal cover image

Published In

Lancet Rheumatol

DOI

EISSN

2665-9913

Publication Date

March 2023

Volume

5

Issue

3

Start / End Page

e151 / e165

Location

England

Related Subject Headings

  • United States
  • Lupus Erythematosus, Systemic
  • Humans
  • Genomics
  • Gene Expression Profiling
  • Epigenomics
  • Artificial Intelligence
  • 3202 Clinical sciences