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Association of Joint Genetic and Social Environmental Risks With Incident Myocardial Infarction: Results From the Health and Retirement Study.

Publication ,  Journal Article
Tang, J; Sheng, C; Wu, YY; Yan, LL; Wu, C
Published in: Journal of the American Heart Association
March 2023

Background Myocardial infarction (MI) is a significant clinical and public health problem worldwide. However, little research has assessed the interplay between genetic susceptibility and social environment in the development of MI. Methods and Results Data were from the HRS (Health and Retirement Study). The polygenic risk score and polysocial score for MI were classified as low, intermediate, and high. Using Cox regression models, we assessed the race-specific association of polygenic score and polysocial score with MI and examined the association between polysocial score and MI in each polygenic risk score category. We also examined the joint effect of genetic (low, intermediate, and high) and social environmental risks (low/intermediate, high) on MI. A total of 612 Black and 4795 White adults aged ≥65 years initially free of MI were included. We found a risk gradient of MI across the polygenic risk score and polysocial score among White participants; no significant risk gradient across the polygenic risk score was found among Black participants. A disadvantaged social environment was associated with a higher risk of incident MI among older White adults with intermediate and high genetic risk but not those with low genetic risk. We revealed the joint effect of genetics and social environment in the development of MI among White participants. Conclusions Living in a favorable social environment is particularly important for people with intermediate and high genetic risk for MI. It is critical to developing tailored interventions to improve social environment for disease prevention, especially among adults with a relatively high genetic risk.

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Published In

Journal of the American Heart Association

DOI

EISSN

2047-9980

ISSN

2047-9980

Publication Date

March 2023

Volume

12

Issue

6

Start / End Page

e028200

Related Subject Headings

  • Risk Factors
  • Retirement
  • Proportional Hazards Models
  • Myocardial Infarction
  • Humans
  • Genetic Predisposition to Disease
  • Adult
  • 1102 Cardiorespiratory Medicine and Haematology
 

Citation

APA
Chicago
ICMJE
MLA
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Tang, J., Sheng, C., Wu, Y. Y., Yan, L. L., & Wu, C. (2023). Association of Joint Genetic and Social Environmental Risks With Incident Myocardial Infarction: Results From the Health and Retirement Study. Journal of the American Heart Association, 12(6), e028200. https://doi.org/10.1161/jaha.122.028200
Tang, Junhan, Chen Sheng, Yan Yan Wu, Lijing L. Yan, and Chenkai Wu. “Association of Joint Genetic and Social Environmental Risks With Incident Myocardial Infarction: Results From the Health and Retirement Study.Journal of the American Heart Association 12, no. 6 (March 2023): e028200. https://doi.org/10.1161/jaha.122.028200.
Tang J, Sheng C, Wu YY, Yan LL, Wu C. Association of Joint Genetic and Social Environmental Risks With Incident Myocardial Infarction: Results From the Health and Retirement Study. Journal of the American Heart Association. 2023 Mar;12(6):e028200.
Tang, Junhan, et al. “Association of Joint Genetic and Social Environmental Risks With Incident Myocardial Infarction: Results From the Health and Retirement Study.Journal of the American Heart Association, vol. 12, no. 6, Mar. 2023, p. e028200. Epmc, doi:10.1161/jaha.122.028200.
Tang J, Sheng C, Wu YY, Yan LL, Wu C. Association of Joint Genetic and Social Environmental Risks With Incident Myocardial Infarction: Results From the Health and Retirement Study. Journal of the American Heart Association. 2023 Mar;12(6):e028200.
Journal cover image

Published In

Journal of the American Heart Association

DOI

EISSN

2047-9980

ISSN

2047-9980

Publication Date

March 2023

Volume

12

Issue

6

Start / End Page

e028200

Related Subject Headings

  • Risk Factors
  • Retirement
  • Proportional Hazards Models
  • Myocardial Infarction
  • Humans
  • Genetic Predisposition to Disease
  • Adult
  • 1102 Cardiorespiratory Medicine and Haematology