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Prediction and Control in DNA Nanotechnology.

Publication ,  Journal Article
DeLuca, M; Sensale, S; Lin, P-A; Arya, G
Published in: ACS applied bio materials
February 2024

DNA nanotechnology is a rapidly developing field that uses DNA as a building material for nanoscale structures. Key to the field's development has been the ability to accurately describe the behavior of DNA nanostructures using simulations and other modeling techniques. In this Review, we present various aspects of prediction and control in DNA nanotechnology, including the various scales of molecular simulation, statistical mechanics, kinetic modeling, continuum mechanics, and other prediction methods. We also address the current uses of artificial intelligence and machine learning in DNA nanotechnology. We discuss how experiments and modeling are synergistically combined to provide control over device behavior, allowing scientists to design molecular structures and dynamic devices with confidence that they will function as intended. Finally, we identify processes and scenarios where DNA nanotechnology lacks sufficient prediction ability and suggest possible solutions to these weak areas.

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Published In

ACS applied bio materials

DOI

EISSN

2576-6422

ISSN

2576-6422

Publication Date

February 2024

Volume

7

Issue

2

Start / End Page

626 / 645

Related Subject Headings

  • Nanotechnology
  • Nanostructures
  • DNA
  • Computer Simulation
  • Artificial Intelligence
  • 4016 Materials engineering
  • 4003 Biomedical engineering
  • 3403 Macromolecular and materials chemistry
 

Citation

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DeLuca, M., Sensale, S., Lin, P.-A., & Arya, G. (2024). Prediction and Control in DNA Nanotechnology. ACS Applied Bio Materials, 7(2), 626–645. https://doi.org/10.1021/acsabm.2c01045
DeLuca, Marcello, Sebastian Sensale, Po-An Lin, and Gaurav Arya. “Prediction and Control in DNA Nanotechnology.ACS Applied Bio Materials 7, no. 2 (February 2024): 626–45. https://doi.org/10.1021/acsabm.2c01045.
DeLuca M, Sensale S, Lin P-A, Arya G. Prediction and Control in DNA Nanotechnology. ACS applied bio materials. 2024 Feb;7(2):626–45.
DeLuca, Marcello, et al. “Prediction and Control in DNA Nanotechnology.ACS Applied Bio Materials, vol. 7, no. 2, Feb. 2024, pp. 626–45. Epmc, doi:10.1021/acsabm.2c01045.
DeLuca M, Sensale S, Lin P-A, Arya G. Prediction and Control in DNA Nanotechnology. ACS applied bio materials. 2024 Feb;7(2):626–645.

Published In

ACS applied bio materials

DOI

EISSN

2576-6422

ISSN

2576-6422

Publication Date

February 2024

Volume

7

Issue

2

Start / End Page

626 / 645

Related Subject Headings

  • Nanotechnology
  • Nanostructures
  • DNA
  • Computer Simulation
  • Artificial Intelligence
  • 4016 Materials engineering
  • 4003 Biomedical engineering
  • 3403 Macromolecular and materials chemistry