Clinicoserological insights into patients with immune checkpoint inhibitor-induced myasthenia gravis.
To compare the immunopathology of immune checkpoint inhibitor-induced myasthenia gravis (ICI-MG) and idiopathic MG, we profiled the respective AChR autoantibody pathogenic properties. Of three ICI-MG patients with AChR autoantibodies, only one showed complement activation and modulation/blocking potency, resembling idiopathic MG. In contrast, AChR autoantibody-mediated effector functions were not detected in the other two patients, questioning the role of their AChR autoantibodies as key mediators of pathology. The contrasting properties of AChR autoantibodies in these cases challenge the accuracy of serological testing in establishing definite ICI-MG diagnoses and underscore the importance of a thorough clinical assessment when evaluating ICI-related adverse events.
Duke Scholars
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Related Subject Headings
- Receptors, Cholinergic
- Myasthenia Gravis
- Immune Checkpoint Inhibitors
- Humans
- Complement Activation
- Autoantibodies
- 5203 Clinical and health psychology
- 3209 Neurosciences
- 1109 Neurosciences
- 1103 Clinical Sciences
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Receptors, Cholinergic
- Myasthenia Gravis
- Immune Checkpoint Inhibitors
- Humans
- Complement Activation
- Autoantibodies
- 5203 Clinical and health psychology
- 3209 Neurosciences
- 1109 Neurosciences
- 1103 Clinical Sciences