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Regulated cell death pathways in cardiomyopathy.

Publication ,  Journal Article
Sheng, S-Y; Li, J-M; Hu, X-Y; Wang, Y
Published in: Acta Pharmacol Sin
August 2023

Heart disease is a worldwide health menace. Both intractable primary and secondary cardiomyopathies contribute to malignant cardiac dysfunction and mortality. One of the key cellular processes associated with cardiomyopathy is cardiomyocyte death. Cardiomyocytes are terminally differentiated cells with very limited regenerative capacity. Various insults can lead to irreversible damage of cardiomyocytes, contributing to progression of cardiac dysfunction. Accumulating evidence indicates that majority of cardiomyocyte death is executed by regulating molecular pathways, including apoptosis, ferroptosis, autophagy, pyroptosis, and necroptosis. Importantly, these forms of regulated cell death (RCD) are cardinal features in the pathogenesis of various cardiomyopathies, including dilated cardiomyopathy, diabetic cardiomyopathy, sepsis-induced cardiomyopathy, and drug-induced cardiomyopathy. The relevance between abnormity of RCD with adverse outcome of cardiomyopathy has been unequivocally evident. Therefore, there is an urgent need to uncover the molecular and cellular mechanisms for RCD in order to better understand the pathogenesis of cardiomyopathies. In this review, we summarize the latest progress from studies on RCD pathways in cardiomyocytes in context of the pathogenesis of cardiomyopathies, with particular emphasis on apoptosis, necroptosis, ferroptosis, autophagy, and pyroptosis. We also elaborate the crosstalk among various forms of RCD in pathologically stressed myocardium and the prospects of therapeutic applications targeted to various cell death pathways.

Duke Scholars

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Published In

Acta Pharmacol Sin

DOI

EISSN

1745-7254

Publication Date

August 2023

Volume

44

Issue

8

Start / End Page

1521 / 1535

Location

United States

Related Subject Headings

  • Regulated Cell Death
  • Pharmacology & Pharmacy
  • Myocardium
  • Humans
  • Heart Diseases
  • Diabetic Cardiomyopathies
  • Apoptosis
  • 3214 Pharmacology and pharmaceutical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences
 

Citation

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Sheng, S.-Y., Li, J.-M., Hu, X.-Y., & Wang, Y. (2023). Regulated cell death pathways in cardiomyopathy. Acta Pharmacol Sin, 44(8), 1521–1535. https://doi.org/10.1038/s41401-023-01068-9
Sheng, Shu-Yuan, Jia-Min Li, Xin-Yang Hu, and Yibin Wang. “Regulated cell death pathways in cardiomyopathy.Acta Pharmacol Sin 44, no. 8 (August 2023): 1521–35. https://doi.org/10.1038/s41401-023-01068-9.
Sheng S-Y, Li J-M, Hu X-Y, Wang Y. Regulated cell death pathways in cardiomyopathy. Acta Pharmacol Sin. 2023 Aug;44(8):1521–35.
Sheng, Shu-Yuan, et al. “Regulated cell death pathways in cardiomyopathy.Acta Pharmacol Sin, vol. 44, no. 8, Aug. 2023, pp. 1521–35. Pubmed, doi:10.1038/s41401-023-01068-9.
Sheng S-Y, Li J-M, Hu X-Y, Wang Y. Regulated cell death pathways in cardiomyopathy. Acta Pharmacol Sin. 2023 Aug;44(8):1521–1535.
Journal cover image

Published In

Acta Pharmacol Sin

DOI

EISSN

1745-7254

Publication Date

August 2023

Volume

44

Issue

8

Start / End Page

1521 / 1535

Location

United States

Related Subject Headings

  • Regulated Cell Death
  • Pharmacology & Pharmacy
  • Myocardium
  • Humans
  • Heart Diseases
  • Diabetic Cardiomyopathies
  • Apoptosis
  • 3214 Pharmacology and pharmaceutical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences