Pathological function of transient receptor potential canonical 6 channel in key central nervous system diseases: Its prospects as drug targets

Transient receptor potential canonical 6 (TRPC6) is a non-selective cation channel, which is involved in various physiological processes, including neuronal axonal growth cone guidance, promotion of dendritic growth and excitatory synaptic formation. Recent studies have shown that TRPC6 participates in many pathological process of central nervous system (CNS) diseases. Therefore, this review focuses on physiological roles of TRPC6, and its pathological roles in CNS, i.e. stroke, Alzheimer disease and epilepsy. We go on to discuss the research development of TRPC6 as drug targets. Finally, we overview and discuss the problems to be solved in further research, and the prospect of TRPC6 as a promising target for drug development.

Duke Scholars

Author Zhongwei Qu