Skip to main content
Journal cover image

Cognitive-motor dual-task interference in adults with sickle cell disease.

Publication ,  Journal Article
Subramaniam, AP; Oyedeji, CI; Parikh, JS; Feld, JA; Strouse, JJ
Published in: Gait & posture
May 2023

Sickle cell disease (SCD) is a genetic disorder that causes physical and cognitive impairment due to hemolysis, painful vaso-occlusion episodes, joint avascular necrosis, and strokes. As individuals with SCD age and develop conditions impacting their physical and cognitive function, their ability to multitask successfully and safely may decline. Cognitive-motor dual-task interference occurs when there is deterioration in one or both tasks while dual-tasking relative to single-tasking. Dual-task assessment (DTA) is a valuable measure of physical and cognitive function; however, there is limited data on DTA in adults with SCD.Is DTA a feasible and safe method of measuring physical and cognitive function in adults with SCD? What patterns of cognitive-motor interference occur in adults with SCD?We enrolled 40 adults with SCD (mean age 44 years, range 20-71) in a single-center prospective cohort study. We used usual gait speed as the measure of motor performance and verbal fluency (F, A, and S) as the measure of cognitive performance. We measured feasibility as the proportion of consented participants able to complete the DTA. We calculated the relative dual-task effect (DTE %) for each task and identified patterns of dual-task interference.Most consented participants completed the DTA (91%, 40/44) and there were no adverse events. There were 3 main dual-task interference patterns for the first trial using letter 'A': Motor Interference (53%, n = 21), Mutual Interference (23%, n = 9), and Cognitive-Priority Tradeoff (15%, n = 6). For the second trial using letter 'S', there were two main dual-task interference patterns: Cognitive-Priority Tradeoff (53%, n = 21) and Motor Interference (25%, n = 10).DTA was feasible and safe in adults with SCD. We identified specific patterns of cognitive-motor interference. This study supports further evaluation of DTA as a potentially useful tool to measure physical and cognitive function in ambulatory adults with SCD.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Gait & posture

DOI

EISSN

1879-2219

ISSN

0966-6362

Publication Date

May 2023

Volume

102

Start / End Page

164 / 170

Related Subject Headings

  • Young Adult
  • Walking
  • Prospective Studies
  • Orthopedics
  • Middle Aged
  • Humans
  • Gait
  • Cognitive Dysfunction
  • Cognition
  • Anemia, Sickle Cell
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Subramaniam, A. P., Oyedeji, C. I., Parikh, J. S., Feld, J. A., & Strouse, J. J. (2023). Cognitive-motor dual-task interference in adults with sickle cell disease. Gait & Posture, 102, 164–170. https://doi.org/10.1016/j.gaitpost.2023.03.009
Subramaniam, Arvind P., Charity I. Oyedeji, Jhana S. Parikh, Jody A. Feld, and John J. Strouse. “Cognitive-motor dual-task interference in adults with sickle cell disease.Gait & Posture 102 (May 2023): 164–70. https://doi.org/10.1016/j.gaitpost.2023.03.009.
Subramaniam AP, Oyedeji CI, Parikh JS, Feld JA, Strouse JJ. Cognitive-motor dual-task interference in adults with sickle cell disease. Gait & posture. 2023 May;102:164–70.
Subramaniam, Arvind P., et al. “Cognitive-motor dual-task interference in adults with sickle cell disease.Gait & Posture, vol. 102, May 2023, pp. 164–70. Epmc, doi:10.1016/j.gaitpost.2023.03.009.
Subramaniam AP, Oyedeji CI, Parikh JS, Feld JA, Strouse JJ. Cognitive-motor dual-task interference in adults with sickle cell disease. Gait & posture. 2023 May;102:164–170.
Journal cover image

Published In

Gait & posture

DOI

EISSN

1879-2219

ISSN

0966-6362

Publication Date

May 2023

Volume

102

Start / End Page

164 / 170

Related Subject Headings

  • Young Adult
  • Walking
  • Prospective Studies
  • Orthopedics
  • Middle Aged
  • Humans
  • Gait
  • Cognitive Dysfunction
  • Cognition
  • Anemia, Sickle Cell