Immunogenicity of the BA.1 and BA.4/BA.5 SARS-CoV-2 Bivalent Boosts: Preliminary Results from the COVAIL Randomized Clinical Trial.
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, Journal Article
Branche, AR; Rouphael, NG; Losada, C; Baden, LR; Anderson, EJ; Luetkemeyer, AF; Diemert, DJ; Winokur, PL; Presti, RM; Kottkamp, AC; Falsey, AR ...
Published in: medRxiv
March 31, 2023
In a randomized clinical trial, we compare early neutralizing antibody responses after boosting with bivalent SARS-CoV-2 mRNA vaccines based on either BA.1 or BA.4/BA.5 Omicron spike protein combined with wildtype spike. Responses against SARS-CoV-2 variants exhibited the greatest reduction in titers against currently circulating Omicron subvariants for both bivalent vaccines.
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medRxiv
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Publication Date
March 31, 2023
Location
United States
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Branche, A. R., Rouphael, N. G., Losada, C., Baden, L. R., Anderson, E. J., Luetkemeyer, A. F., … Beigel, J. H. (2023). Immunogenicity of the BA.1 and BA.4/BA.5 SARS-CoV-2 Bivalent Boosts: Preliminary Results from the COVAIL Randomized Clinical Trial. MedRxiv. https://doi.org/10.1101/2023.01.31.23285306
Branche, Angela R., Nadine G. Rouphael, Cecilia Losada, Lindsey R. Baden, Evan J. Anderson, Anne F. Luetkemeyer, David J. Diemert, et al. “Immunogenicity of the BA.1 and BA.4/BA.5 SARS-CoV-2 Bivalent Boosts: Preliminary Results from the COVAIL Randomized Clinical Trial.” MedRxiv, March 31, 2023. https://doi.org/10.1101/2023.01.31.23285306.
Branche AR, Rouphael NG, Losada C, Baden LR, Anderson EJ, Luetkemeyer AF, et al. Immunogenicity of the BA.1 and BA.4/BA.5 SARS-CoV-2 Bivalent Boosts: Preliminary Results from the COVAIL Randomized Clinical Trial. medRxiv. 2023 Mar 31;
Branche, Angela R., et al. “Immunogenicity of the BA.1 and BA.4/BA.5 SARS-CoV-2 Bivalent Boosts: Preliminary Results from the COVAIL Randomized Clinical Trial.” MedRxiv, Mar. 2023. Pubmed, doi:10.1101/2023.01.31.23285306.
Branche AR, Rouphael NG, Losada C, Baden LR, Anderson EJ, Luetkemeyer AF, Diemert DJ, Winokur PL, Presti RM, Kottkamp AC, Falsey AR, Frey SE, Rupp R, Bäcker M, Novak RM, Walter EB, Jackson LA, Little SJ, Immergluck LC, Mahgoub SM, Whitaker JA, Babu TM, Goepfert PA, Fusco DN, Atmar RL, Posavad CM, Netzl A, Smith DJ, Telu K, Mu J, Makowski M, Makhene MK, Sonja C, Montefiori DC, Roberts PC, Beigel JH. Immunogenicity of the BA.1 and BA.4/BA.5 SARS-CoV-2 Bivalent Boosts: Preliminary Results from the COVAIL Randomized Clinical Trial. medRxiv. 2023 Mar 31;
Published In
medRxiv
DOI
Publication Date
March 31, 2023
Location
United States