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Pro-inflammatory cytokine responses to Naegleria fowleri infection.

Publication ,  Journal Article
Chen, C-W; Moseman, EA
Published in: Front Trop Dis
2022

Naegleria fowleri, or the "brain-eating amoeba," is responsible for a rare, but lethal, infection known as primary amoebic meningoencephalitis (PAM). Confirmed PAM cases have seen both a rise in numbers, as well as expansion of geographic range over the past several decades. There is no effective therapy for PAM and the clinical prognosis remains grim with a mortality rate over 95%. The role of the immune response in disease prevention and disease severity remains unclear. In this review, we explore potential roles of inflammatory immune responses to N. fowleri in disease pathogenesis with a primary focus on pro-inflammatory cytokines IL-1, IL-6, and TNFα. We also discuss modulating proinflammatory cytokines as an additional immune therapy in PAM treatment.

Duke Scholars

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Published In

Front Trop Dis

DOI

EISSN

2673-7515

Publication Date

2022

Volume

3

Location

Switzerland
 

Citation

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Chicago
ICMJE
MLA
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Chen, C.-W., & Moseman, E. A. (2022). Pro-inflammatory cytokine responses to Naegleria fowleri infection. Front Trop Dis, 3. https://doi.org/10.3389/fitd.2022.1082334
Chen, Ching-Wen, and E Ashley Moseman. “Pro-inflammatory cytokine responses to Naegleria fowleri infection.Front Trop Dis 3 (2022). https://doi.org/10.3389/fitd.2022.1082334.
Chen C-W, Moseman EA. Pro-inflammatory cytokine responses to Naegleria fowleri infection. Front Trop Dis. 2022;3.
Chen, Ching-Wen, and E. Ashley Moseman. “Pro-inflammatory cytokine responses to Naegleria fowleri infection.Front Trop Dis, vol. 3, 2022. Pubmed, doi:10.3389/fitd.2022.1082334.
Chen C-W, Moseman EA. Pro-inflammatory cytokine responses to Naegleria fowleri infection. Front Trop Dis. 2022;3.

Published In

Front Trop Dis

DOI

EISSN

2673-7515

Publication Date

2022

Volume

3

Location

Switzerland