Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel

Pathogenesis of autoimmune disease.

Publication ,  Journal Article
Pisetsky, DS
Published in: Nat Rev Nephrol
August 2023

Autoimmune diseases are a diverse group of conditions characterized by aberrant B cell and T cell reactivity to normal constituents of the host. These diseases occur widely and affect individuals of all ages, especially women. Among these diseases, the most prominent immunological manifestation is the production of autoantibodies, which provide valuable biomarkers for diagnosis, classification and disease activity. Although T cells have a key role in pathogenesis, they are technically more difficult to assay. In general, autoimmune disease results from an interplay between a genetic predisposition and environmental factors. Genetic predisposition to autoimmunity is complex and can involve multiple genes that regulate the function of immune cell populations. Less frequently, autoimmunity can result from single-gene mutations that affect key regulatory pathways. Infection seems to be a common trigger for autoimmune disease, although the microbiota can also influence pathogenesis. As shown in seminal studies, patients may express autoantibodies many years before the appearance of clinical or laboratory signs of disease - a period called pre-clinical autoimmunity. Monitoring autoantibody expression in at-risk populations may therefore enable early detection and the initiation of therapy to prevent or attenuate tissue damage. Autoimmunity may not be static, however, and remission can be achieved by some patients treated with current agents.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Nat Rev Nephrol

DOI

EISSN

1759-507X

Publication Date

August 2023

Volume

19

Issue

8

Start / End Page

509 / 524

Location

England

Related Subject Headings

  • Urology & Nephrology
  • T-Lymphocytes
  • Humans
  • Genetic Predisposition to Disease
  • Female
  • Autoimmunity
  • Autoimmune Diseases
  • Autoantibodies
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Pisetsky, D. S. (2023). Pathogenesis of autoimmune disease. Nat Rev Nephrol, 19(8), 509–524. https://doi.org/10.1038/s41581-023-00720-1
Pisetsky, David S. “Pathogenesis of autoimmune disease.Nat Rev Nephrol 19, no. 8 (August 2023): 509–24. https://doi.org/10.1038/s41581-023-00720-1.
Pisetsky DS. Pathogenesis of autoimmune disease. Nat Rev Nephrol. 2023 Aug;19(8):509–24.
Pisetsky, David S. “Pathogenesis of autoimmune disease.Nat Rev Nephrol, vol. 19, no. 8, Aug. 2023, pp. 509–24. Pubmed, doi:10.1038/s41581-023-00720-1.
Pisetsky DS. Pathogenesis of autoimmune disease. Nat Rev Nephrol. 2023 Aug;19(8):509–524.

Published In

Nat Rev Nephrol

DOI

EISSN

1759-507X

Publication Date

August 2023

Volume

19

Issue

8

Start / End Page

509 / 524

Location

England

Related Subject Headings

  • Urology & Nephrology
  • T-Lymphocytes
  • Humans
  • Genetic Predisposition to Disease
  • Female
  • Autoimmunity
  • Autoimmune Diseases
  • Autoantibodies
  • 3202 Clinical sciences
  • 1103 Clinical Sciences