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Prenatal Substance Exposure: Associations with Neurodevelopment in Middle Childhood.

Publication ,  Journal Article
Conradt, E; McGrath, M; Knapp, E; Li, X; Musci, RJ; Mansolf, M; Deoni, S; Sathyanarayana, S; Ondersma, SJ; Lester, BM ...
Published in: Am J Perinatol
May 2024

OBJECTIVE:  Single-substance exposure effects on neurodevelopmental outcomes, such as problem behavior and intelligence quotient (IQ), have been studied in children for decades. However, the long-term consequences of polysubstance exposure are poorly understood. STUDY DESIGN:  Longitudinal neurodevelopmental data were gathered from cohorts across the United States through the Environmental Influences on Child Health Outcomes Program. Data on prenatal exposure to opioids, nicotine, marijuana, and alcohol were collected from children ages 6 to 11 years (N = 256). Problem behavior was assessed using the Child Behavior Checklist (school-age version), and verbal IQ (VIQ) and performance IQ (PIQ) were assessed using the Weschler Intelligence Scale for Children, Fifth Edition. We first identified latent profiles in the overall sample, then evaluated differences in profile membership for children with and without prenatal substance exposure. RESULTS:  Latent profile analysis identified two mutually exclusive categories: average VIQ and PIQ, with typical problem behavior, and below-average VIQ with average PIQ and clinically significant problem behavior. Children with prenatal nicotine and polysubstance exposures were more likely to be classified in the below-average VIQ, elevated problem behavior profile compared with children without prenatal nicotine exposure. CONCLUSION:  The presence of clinically significant behavior problems in children with average PIQ, but below-average VIQ, could represent a unique endophenotype related to prenatal nicotine exposure in the context of other prenatal substance exposures. KEY POINTS: · The neurodevelopmental consequences of prenatal polysubstance exposure are poorly understood.. · Children with prenatal polysubstance exposure exhibited reduced IQ and elevated problem behavior.. · We found significant behavior problems in children with average PIQ and below-average VIQ.. · This may represent a unique endophenotype related to prenatal nicotine exposure..

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Published In

Am J Perinatol

DOI

EISSN

1098-8785

Publication Date

May 2024

Volume

41

Issue

S 01

Start / End Page

e1944 / e1954

Location

United States

Related Subject Headings

  • United States
  • Substance-Related Disorders
  • Problem Behavior
  • Prenatal Exposure Delayed Effects
  • Pregnancy
  • Obstetrics & Reproductive Medicine
  • Nicotine
  • Neurodevelopmental Disorders
  • Male
  • Longitudinal Studies
 

Citation

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Conradt, E., McGrath, M., Knapp, E., Li, X., Musci, R. J., Mansolf, M., … program collaborators for Environmental Influences on Child Health Outcomes, . (2024). Prenatal Substance Exposure: Associations with Neurodevelopment in Middle Childhood. Am J Perinatol, 41(S 01), e1944–e1954. https://doi.org/10.1055/a-2090-5293
Conradt, Elisabeth, Monica McGrath, Emily Knapp, Xiuhong Li, Rashelle J. Musci, Maxwell Mansolf, Sean Deoni, et al. “Prenatal Substance Exposure: Associations with Neurodevelopment in Middle Childhood.Am J Perinatol 41, no. S 01 (May 2024): e1944–54. https://doi.org/10.1055/a-2090-5293.
Conradt E, McGrath M, Knapp E, Li X, Musci RJ, Mansolf M, et al. Prenatal Substance Exposure: Associations with Neurodevelopment in Middle Childhood. Am J Perinatol. 2024 May;41(S 01):e1944–54.
Conradt, Elisabeth, et al. “Prenatal Substance Exposure: Associations with Neurodevelopment in Middle Childhood.Am J Perinatol, vol. 41, no. S 01, May 2024, pp. e1944–54. Pubmed, doi:10.1055/a-2090-5293.
Conradt E, McGrath M, Knapp E, Li X, Musci RJ, Mansolf M, Deoni S, Sathyanarayana S, Ondersma SJ, Lester BM, program collaborators for Environmental Influences on Child Health Outcomes. Prenatal Substance Exposure: Associations with Neurodevelopment in Middle Childhood. Am J Perinatol. 2024 May;41(S 01):e1944–e1954.
Journal cover image

Published In

Am J Perinatol

DOI

EISSN

1098-8785

Publication Date

May 2024

Volume

41

Issue

S 01

Start / End Page

e1944 / e1954

Location

United States

Related Subject Headings

  • United States
  • Substance-Related Disorders
  • Problem Behavior
  • Prenatal Exposure Delayed Effects
  • Pregnancy
  • Obstetrics & Reproductive Medicine
  • Nicotine
  • Neurodevelopmental Disorders
  • Male
  • Longitudinal Studies