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3D osteoarthritic changes in TMJ condylar morphology correlates with specific systemic and local biomarkers of disease.

Publication ,  Journal Article
Cevidanes, LHS; Walker, D; Schilling, J; Sugai, J; Giannobile, W; Paniagua, B; Benavides, E; Zhu, H; Marron, JS; Jung, BT; Baranowski, D ...
Published in: Osteoarthritis Cartilage
October 2014

OBJECTIVE: To assess 3D morphological variations and local and systemic biomarker profiles in subjects with a diagnosis of temporomandibular joint osteoarthritis (TMJ OA). DESIGN: Twenty-eight patients with long-term TMJ OA (39.9 ± 16 years), 12 patients at initial diagnosis of OA (47.4 ± 16.1 years), and 12 healthy controls (41.8 ± 12.2 years) were recruited. All patients were female and had cone beam CT scans taken. TMJ arthrocentesis and venipuncture were performed on 12 OA and 12 age-matched healthy controls. Serum and synovial fluid levels of 50 biomarkers of arthritic inflammation were quantified by protein microarrays. Shape Analysis MANCOVA tested statistical correlations between biomarker levels and variations in condylar morphology. RESULTS: Compared with healthy controls, the OA average condyle was significantly smaller in all dimensions except its anterior surface, with areas indicative of bone resorption along the articular surface, particularly in the lateral pole. Synovial fluid levels of ANG, GDF15, TIMP-1, CXCL16, MMP-3 and MMP-7 were significantly correlated with bone apposition of the condylar anterior surface. Serum levels of ENA-78, MMP-3, PAI-1, VE-Cadherin, VEGF, GM-CSF, TGFβb1, IFNγg, TNFαa, IL-1αa, and IL-6 were significantly correlated with flattening of the lateral pole. Expression levels of ANG were significantly correlated with the articular morphology in healthy controls. CONCLUSIONS: Bone resorption at the articular surface, particularly at the lateral pole was statistically significant at initial diagnosis of TMJ OA. Synovial fluid levels of ANG, GDF15, TIMP-1, CXCL16, MMP-3 and MMP-7 were correlated with bone apposition. Serum levels of ENA-78, MMP-3, PAI-1, VE-Cadherin, VEGF, GM-CSF, TGFβ1, IFNγ, TNFα, IL-1α, and IL-6 were correlated with bone resorption.

Duke Scholars

Published In

Osteoarthritis Cartilage

DOI

EISSN

1522-9653

Publication Date

October 2014

Volume

22

Issue

10

Start / End Page

1657 / 1667

Location

England

Related Subject Headings

  • Young Adult
  • Temporomandibular Joint Disorders
  • Temporomandibular Joint
  • Synovial Fluid
  • Osteoarthritis
  • Middle Aged
  • Inflammation Mediators
  • Imaging, Three-Dimensional
  • Humans
  • Female
 

Citation

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MLA
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Cevidanes, L. H. S., Walker, D., Schilling, J., Sugai, J., Giannobile, W., Paniagua, B., … Styner, M. (2014). 3D osteoarthritic changes in TMJ condylar morphology correlates with specific systemic and local biomarkers of disease. Osteoarthritis Cartilage, 22(10), 1657–1667. https://doi.org/10.1016/j.joca.2014.06.014
Cevidanes, L. H. S., D. Walker, J. Schilling, J. Sugai, W. Giannobile, B. Paniagua, E. Benavides, et al. “3D osteoarthritic changes in TMJ condylar morphology correlates with specific systemic and local biomarkers of disease.Osteoarthritis Cartilage 22, no. 10 (October 2014): 1657–67. https://doi.org/10.1016/j.joca.2014.06.014.
Cevidanes LHS, Walker D, Schilling J, Sugai J, Giannobile W, Paniagua B, et al. 3D osteoarthritic changes in TMJ condylar morphology correlates with specific systemic and local biomarkers of disease. Osteoarthritis Cartilage. 2014 Oct;22(10):1657–67.
Cevidanes, L. H. S., et al. “3D osteoarthritic changes in TMJ condylar morphology correlates with specific systemic and local biomarkers of disease.Osteoarthritis Cartilage, vol. 22, no. 10, Oct. 2014, pp. 1657–67. Pubmed, doi:10.1016/j.joca.2014.06.014.
Cevidanes LHS, Walker D, Schilling J, Sugai J, Giannobile W, Paniagua B, Benavides E, Zhu H, Marron JS, Jung BT, Baranowski D, Rhodes J, Nackley A, Lim PF, Ludlow JB, Nguyen T, Goncalves JR, Wolford L, Kapila S, Styner M. 3D osteoarthritic changes in TMJ condylar morphology correlates with specific systemic and local biomarkers of disease. Osteoarthritis Cartilage. 2014 Oct;22(10):1657–1667.
Journal cover image

Published In

Osteoarthritis Cartilage

DOI

EISSN

1522-9653

Publication Date

October 2014

Volume

22

Issue

10

Start / End Page

1657 / 1667

Location

England

Related Subject Headings

  • Young Adult
  • Temporomandibular Joint Disorders
  • Temporomandibular Joint
  • Synovial Fluid
  • Osteoarthritis
  • Middle Aged
  • Inflammation Mediators
  • Imaging, Three-Dimensional
  • Humans
  • Female