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SARS CoV subunit vaccine: antibody-mediated neutralisation and enhancement.

Publication ,  Journal Article
Jaume, M; Yip, MS; Kam, YW; Cheung, CY; Kien, F; Roberts, A; Li, PH; Dutry, I; Escriou, N; Daeron, M; Bruzzone, R; Subbarao, K; Peiris, JSM ...
Published in: Hong Kong medical journal = Xianggang yi xue za zhi
February 2012

1. A SARS vaccine was produced based on recombinant native full-length Spike-protein trimers (triSpike) and efficient establishment of a vaccination procedure in rodents. 2. Antibody-mediated enhancement of SARS-CoV infection with anti-SARS-CoV Spike immune-serum was observed in vitro. 3. Antibody-mediated infection of SARS-CoV triggers entry into human haematopoietic cells via an FcγR-dependent and ACE2-, pH-, cysteine-protease-independent pathways. 4. The antibody-mediated enhancement phenomenon is not a mandatory component of the humoral immune response elicited by SARS vaccines, as pure neutralising antibody only could be obtained. 5. Occurrence of immune-mediated enhancement of SARS-CoV infection raises safety concerns regarding the use of SARS-CoV vaccine in humans and enables new ways to investigate SARS pathogenesis (tropism and immune response deregulation).

Duke Scholars

Yiu Wing Kam
Author Yiu Wing Kam DKU Faculty

Published In

Hong Kong medical journal = Xianggang yi xue za zhi

ISSN

1024-2708

Publication Date

February 2012

Volume

18 Suppl 2

Start / End Page

31 / 36

Related Subject Headings

  • Virus Internalization
  • Viral Envelope Proteins
  • Vaccines
  • Spike Glycoprotein, Coronavirus
  • Severe acute respiratory syndrome-related coronavirus
  • Severe Acute Respiratory Syndrome
  • Receptors, Fc
  • Peptidyl-Dipeptidase A
  • Monocytes
  • Mice, Inbred BALB C
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Jaume, M., Yip, M. S., Kam, Y. W., Cheung, C. Y., Kien, F., Roberts, A., … Altmeyer, R. (2012). SARS CoV subunit vaccine: antibody-mediated neutralisation and enhancement. Hong Kong Medical Journal = Xianggang Yi Xue Za Zhi, 18 Suppl 2, 31–36.
Jaume, M., M. S. Yip, Y. W. Kam, C. Y. Cheung, F. Kien, A. Roberts, P. H. Li, et al. “SARS CoV subunit vaccine: antibody-mediated neutralisation and enhancement.” Hong Kong Medical Journal = Xianggang Yi Xue Za Zhi 18 Suppl 2 (February 2012): 31–36.
Jaume M, Yip MS, Kam YW, Cheung CY, Kien F, Roberts A, et al. SARS CoV subunit vaccine: antibody-mediated neutralisation and enhancement. Hong Kong medical journal = Xianggang yi xue za zhi. 2012 Feb;18 Suppl 2:31–6.
Jaume, M., et al. “SARS CoV subunit vaccine: antibody-mediated neutralisation and enhancement.” Hong Kong Medical Journal = Xianggang Yi Xue Za Zhi, vol. 18 Suppl 2, Feb. 2012, pp. 31–36.
Jaume M, Yip MS, Kam YW, Cheung CY, Kien F, Roberts A, Li PH, Dutry I, Escriou N, Daeron M, Bruzzone R, Subbarao K, Peiris JSM, Nal B, Altmeyer R. SARS CoV subunit vaccine: antibody-mediated neutralisation and enhancement. Hong Kong medical journal = Xianggang yi xue za zhi. 2012 Feb;18 Suppl 2:31–36.

Published In

Hong Kong medical journal = Xianggang yi xue za zhi

ISSN

1024-2708

Publication Date

February 2012

Volume

18 Suppl 2

Start / End Page

31 / 36

Related Subject Headings

  • Virus Internalization
  • Viral Envelope Proteins
  • Vaccines
  • Spike Glycoprotein, Coronavirus
  • Severe acute respiratory syndrome-related coronavirus
  • Severe Acute Respiratory Syndrome
  • Receptors, Fc
  • Peptidyl-Dipeptidase A
  • Monocytes
  • Mice, Inbred BALB C