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Known and missing left ventricular ejection fraction and survival in patients with heart failure: a MAGGIC meta-analysis report.

Publication ,  Journal Article
Poppe, KK; Squire, IB; Whalley, GA; Køber, L; McAlister, FA; McMurray, JJV; Pocock, S; Earle, NJ; Berry, C; Doughty, RN ...
Published in: Eur J Heart Fail
November 2013

AIMS: Treatment of patients with heart failure (HF) relies on measurement of LVEF. However, the extent to which EF is recorded varies markedly. We sought to characterize the patient group that is missing a measure of EF, and to explore the association between missing EF and outcome. METHODS AND RESULTS: Individual data on 30 445 patients from 28 observational studies in the Meta-Analysis Global Group in Chronic Heart Failure (MAGGIC) project were used to compare the prevalence of co-morbidities and outcome across three groups of HF patients: those with missing EF (HF-mEF), reduced EF (HF-REF), and preserved EF (HF-PEF). A total of 29% had HF-mEF, 52% HF-REF, and 19% HF-PEF. Compared with patients in whom EF was known, patients with HF-mEF were older, had a greater prevalence of COPD and previous stroke, and were smokers. Patients with HF-mEF were less likely to receive evidence-based treatment than those with HF-REF. Adjusted mortality in HF-mEF was similar to that in HF-REF and greater than that in HF-PEF at 3 years [HF-REF, hazard ratio (HR) 1.03, 95% confidence interval (CI) 0.95-1.12); HF-PEF, HR 0.78, 95% CI 0.71-0.86]. CONCLUSION: Missing EF is common. The short- and long-term outcome of patients with HF-mEF is poor and they exhibit different co-morbidity profiles and treatment patterns compared with patients with known EF. HF patients with missing EF represent a high risk group.

Duke Scholars

Published In

Eur J Heart Fail

DOI

EISSN

1879-0844

Publication Date

November 2013

Volume

15

Issue

11

Start / End Page

1220 / 1227

Location

England

Related Subject Headings

  • Stroke Volume
  • Prognosis
  • Outcome and Process Assessment, Health Care
  • Multivariate Analysis
  • Middle Aged
  • Male
  • Humans
  • Heart Failure
  • Female
  • Echocardiography
 

Citation

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Poppe, K. K., Squire, I. B., Whalley, G. A., Køber, L., McAlister, F. A., McMurray, J. J. V., … Meta-Analysis Global Group in Chronic Heart Failure, . (2013). Known and missing left ventricular ejection fraction and survival in patients with heart failure: a MAGGIC meta-analysis report. Eur J Heart Fail, 15(11), 1220–1227. https://doi.org/10.1093/eurjhf/hft101
Poppe, Katrina K., Iain B. Squire, Gillian A. Whalley, Lars Køber, Finlay A. McAlister, John J. V. McMurray, Stuart Pocock, et al. “Known and missing left ventricular ejection fraction and survival in patients with heart failure: a MAGGIC meta-analysis report.Eur J Heart Fail 15, no. 11 (November 2013): 1220–27. https://doi.org/10.1093/eurjhf/hft101.
Poppe KK, Squire IB, Whalley GA, Køber L, McAlister FA, McMurray JJV, et al. Known and missing left ventricular ejection fraction and survival in patients with heart failure: a MAGGIC meta-analysis report. Eur J Heart Fail. 2013 Nov;15(11):1220–7.
Poppe, Katrina K., et al. “Known and missing left ventricular ejection fraction and survival in patients with heart failure: a MAGGIC meta-analysis report.Eur J Heart Fail, vol. 15, no. 11, Nov. 2013, pp. 1220–27. Pubmed, doi:10.1093/eurjhf/hft101.
Poppe KK, Squire IB, Whalley GA, Køber L, McAlister FA, McMurray JJV, Pocock S, Earle NJ, Berry C, Doughty RN, Meta-Analysis Global Group in Chronic Heart Failure. Known and missing left ventricular ejection fraction and survival in patients with heart failure: a MAGGIC meta-analysis report. Eur J Heart Fail. 2013 Nov;15(11):1220–1227.
Journal cover image

Published In

Eur J Heart Fail

DOI

EISSN

1879-0844

Publication Date

November 2013

Volume

15

Issue

11

Start / End Page

1220 / 1227

Location

England

Related Subject Headings

  • Stroke Volume
  • Prognosis
  • Outcome and Process Assessment, Health Care
  • Multivariate Analysis
  • Middle Aged
  • Male
  • Humans
  • Heart Failure
  • Female
  • Echocardiography