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Latent Class Analysis of Prenatal Substance Exposure and Child Behavioral Outcomes.

Publication ,  Journal Article
Maylott, SE; Conradt, E; McGrath, M; Knapp, EA; Li, X; Musci, R; Aschner, J; Avalos, LA; Croen, LA; Deoni, S; Derefinko, K; Elliott, A ...
Published in: J Pediatr
September 2023

OBJECTIVES: To predict behavioral disruptions in middle childhood, we identified latent classes of prenatal substance use. STUDY DESIGN: As part of the Environmental influences on Child Health Outcomes Program, we harmonized prenatal substance use data and child behavior outcomes from 2195 women and their 6- to 11-year-old children across 10 cohorts in the US and used latent class-adjusted regression models to predict parent-rated child behavior. RESULTS: Three latent classes fit the data: low use (90.5%; n = 1986), primarily using no substances; licit use (6.6%; n = 145), mainly using nicotine with a moderate likelihood of using alcohol and marijuana; and illicit use (2.9%; n = 64), predominantly using illicit substances along with a moderate likelihood of using licit substances. Children exposed to primarily licit substances in utero had greater levels of externalizing behavior than children exposed to low or no substances (P = .001, d = .64). Children exposed to illicit substances in utero showed small but significant elevations in internalizing behavior than children exposed to low or no substances (P < .001, d = .16). CONCLUSIONS: The differences in prenatal polysubstance use may increase risk for specific childhood problem behaviors; however, child outcomes appeared comparably adverse for both licit and illicit polysubstance exposure. We highlight the need for similar multicohort, large-scale studies to examine childhood outcomes based on prenatal substance use profiles.

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Published In

J Pediatr

DOI

EISSN

1097-6833

Publication Date

September 2023

Volume

260

Start / End Page

113468

Location

United States

Related Subject Headings

  • Substance-Related Disorders
  • Problem Behavior
  • Prenatal Exposure Delayed Effects
  • Pregnancy
  • Pediatrics
  • Latent Class Analysis
  • Humans
  • Female
  • Child Behavior Disorders
  • Child Behavior
 

Citation

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MLA
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Maylott, S. E., Conradt, E., McGrath, M., Knapp, E. A., Li, X., Musci, R., … program collaborators for Environmental influences on Child Health Outcomes (ECHO). (2023). Latent Class Analysis of Prenatal Substance Exposure and Child Behavioral Outcomes. J Pediatr, 260, 113468. https://doi.org/10.1016/j.jpeds.2023.113468
Maylott, Sarah E., Elisabeth Conradt, Monica McGrath, Emily A. Knapp, Xiuhong Li, Rashelle Musci, Judy Aschner, et al. “Latent Class Analysis of Prenatal Substance Exposure and Child Behavioral Outcomes.J Pediatr 260 (September 2023): 113468. https://doi.org/10.1016/j.jpeds.2023.113468.
Maylott SE, Conradt E, McGrath M, Knapp EA, Li X, Musci R, et al. Latent Class Analysis of Prenatal Substance Exposure and Child Behavioral Outcomes. J Pediatr. 2023 Sep;260:113468.
Maylott, Sarah E., et al. “Latent Class Analysis of Prenatal Substance Exposure and Child Behavioral Outcomes.J Pediatr, vol. 260, Sept. 2023, p. 113468. Pubmed, doi:10.1016/j.jpeds.2023.113468.
Maylott SE, Conradt E, McGrath M, Knapp EA, Li X, Musci R, Aschner J, Avalos LA, Croen LA, Deoni S, Derefinko K, Elliott A, Hofheimer JA, Leve LD, Madan JC, Mansolf M, Murrison LB, Neiderhiser JM, Ozonoff S, Posner J, Salisbury A, Sathyanarayana S, Schweitzer JB, Seashore C, Stabler ME, Young LW, Ondersma SJ, Lester B, program collaborators for Environmental influences on Child Health Outcomes (ECHO). Latent Class Analysis of Prenatal Substance Exposure and Child Behavioral Outcomes. J Pediatr. 2023 Sep;260:113468.
Journal cover image

Published In

J Pediatr

DOI

EISSN

1097-6833

Publication Date

September 2023

Volume

260

Start / End Page

113468

Location

United States

Related Subject Headings

  • Substance-Related Disorders
  • Problem Behavior
  • Prenatal Exposure Delayed Effects
  • Pregnancy
  • Pediatrics
  • Latent Class Analysis
  • Humans
  • Female
  • Child Behavior Disorders
  • Child Behavior