National Kidney Foundation S Primer on Kidney Diseases
Genetics and Kidney Disease (APOL1)
Publication
, Chapter
Crawford, BD; Sampson, MG; Gbadegesin, RA
January 1, 2017
Genetic studies of kidney diseases over the past two decades have provided novel insights into underlying pathophysiologic mechanisms and spurred progress toward the goal of precision medicine. This chapter provides a primer on genetic variation, methods for gene discovery of monogenic kidney diseases (linkage analysis and next-generation sequencing), and identification of risk loci for kidney diseases with complex inheritance (genome-wide association studies [GWAS]). The chapter also briefly discusses the challenges in interpretation of identified variants from next-generation sequencing (NGS).
Duke Scholars
DOI
Publication Date
January 1, 2017
Start / End Page
356 / 359.e1
Citation
APA
Chicago
ICMJE
MLA
NLM
Crawford, B. D., Sampson, M. G., & Gbadegesin, R. A. (2017). Genetics and Kidney Disease (APOL1). In National Kidney Foundation S Primer on Kidney Diseases (pp. 356-359.e1). https://doi.org/10.1016/B978-0-323-47794-9.00037-8
Crawford, B. D., M. G. Sampson, and R. A. Gbadegesin. “Genetics and Kidney Disease (APOL1).” In National Kidney Foundation S Primer on Kidney Diseases, 356-359.e1, 2017. https://doi.org/10.1016/B978-0-323-47794-9.00037-8.
Crawford BD, Sampson MG, Gbadegesin RA. Genetics and Kidney Disease (APOL1). In: National Kidney Foundation S Primer on Kidney Diseases. 2017. p. 356-359.e1.
Crawford, B. D., et al. “Genetics and Kidney Disease (APOL1).” National Kidney Foundation S Primer on Kidney Diseases, 2017, pp. 356-359.e1. Scopus, doi:10.1016/B978-0-323-47794-9.00037-8.
Crawford BD, Sampson MG, Gbadegesin RA. Genetics and Kidney Disease (APOL1). National Kidney Foundation S Primer on Kidney Diseases. 2017. p. 356-359.e1.
DOI
Publication Date
January 1, 2017
Start / End Page
356 / 359.e1