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Interdependencies of the Neuronal, Immune and Tumor Microenvironment in Gliomas.

Publication ,  Journal Article
Yuile, A; Wei, JQ; Mohan, AA; Hotchkiss, KM; Khasraw, M
Published in: Cancers (Basel)
May 21, 2023

Gliomas are the most common primary brain malignancy and are universally fatal. Despite significant breakthrough in understanding tumor biology, treatment breakthroughs have been limited. There is a growing appreciation that major limitations on effective treatment are related to the unique and highly complex glioma tumor microenvironment (TME). The TME consists of multiple different cell types, broadly categorized into tumoral, immune and non-tumoral, non-immune cells. Each group provides significant influence on the others, generating a pro-tumor dynamic with significant immunosuppression. In addition, glioma cells are highly heterogenous with various molecular distinctions on the cellular level. These variations, in turn, lead to their own unique influence on the TME. To develop future treatments, an understanding of this complex TME interplay is needed. To this end, we describe the TME in adult gliomas through interactions between its various components and through various glioma molecular phenotypes.

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Published In

Cancers (Basel)

DOI

ISSN

2072-6694

Publication Date

May 21, 2023

Volume

15

Issue

10

Location

Switzerland

Related Subject Headings

  • 1112 Oncology and Carcinogenesis
 

Citation

APA
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ICMJE
MLA
NLM
Yuile, A., Wei, J. Q., Mohan, A. A., Hotchkiss, K. M., & Khasraw, M. (2023). Interdependencies of the Neuronal, Immune and Tumor Microenvironment in Gliomas. Cancers (Basel), 15(10). https://doi.org/10.3390/cancers15102856
Yuile, Alexander, Joe Q. Wei, Aditya A. Mohan, Kelly M. Hotchkiss, and Mustafa Khasraw. “Interdependencies of the Neuronal, Immune and Tumor Microenvironment in Gliomas.Cancers (Basel) 15, no. 10 (May 21, 2023). https://doi.org/10.3390/cancers15102856.
Yuile A, Wei JQ, Mohan AA, Hotchkiss KM, Khasraw M. Interdependencies of the Neuronal, Immune and Tumor Microenvironment in Gliomas. Cancers (Basel). 2023 May 21;15(10).
Yuile, Alexander, et al. “Interdependencies of the Neuronal, Immune and Tumor Microenvironment in Gliomas.Cancers (Basel), vol. 15, no. 10, May 2023. Pubmed, doi:10.3390/cancers15102856.
Yuile A, Wei JQ, Mohan AA, Hotchkiss KM, Khasraw M. Interdependencies of the Neuronal, Immune and Tumor Microenvironment in Gliomas. Cancers (Basel). 2023 May 21;15(10).

Published In

Cancers (Basel)

DOI

ISSN

2072-6694

Publication Date

May 21, 2023

Volume

15

Issue

10

Location

Switzerland

Related Subject Headings

  • 1112 Oncology and Carcinogenesis