Skip to main content
release_alert
Welcome to the new Scholars 3.0! Read about new features and let us know what you think.
cancel

Evaluation of Autonomic Nervous System Dysfunction in Childhood Obesity and Prader-Willi Syndrome.

Publication ,  Journal Article
Richer, LP; Tan, Q; Butler, MG; Avedzi, HM; DeLorey, DS; Peng, Y; Tun, HM; Sharma, AM; Ainsley, S; Orsso, CE; Triador, L; Freemark, M; Haqq, AM
Published in: International Journal of Molecular Sciences
April 2023

The autonomic nervous system (ANS) may play a role in the distribution of body fat and the development of obesity and its complications. Features of individuals with Prader-Willi syndrome (PWS) impacted by PWS molecular genetic classes suggest alterations in ANS function; however, these have been rarely studied and presented with conflicting results. The aim of this study was to investigate if the ANS function is altered in PWS. In this case-control study, we assessed ANS function in 20 subjects with PWS (6 males/14 females; median age 10.5 years) and 27 body mass index (BMI) z-score-matched controls (19 males/8 females; median age 12.8 years). Standardized non-invasive measures of cardiac baroreflex function, heart rate, blood pressure, heart rate variability, quantitative sudomotor axon reflex tests, and a symptom questionnaire were completed. The increase in heart rate in response to head-up tilt testing was blunted (p < 0.01) in PWS compared to controls. Besides a lower heart rate ratio with Valsalva in PWS (p < 0.01), no significant differences were observed in other measures of cardiac function or sweat production. Findings suggest possible altered sympathetic function in PWS.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

International Journal of Molecular Sciences

DOI

EISSN

1422-0067

ISSN

1422-0067

Publication Date

April 2023

Volume

24

Issue

9

Start / End Page

8013

Related Subject Headings

  • Prader-Willi Syndrome
  • Pediatric Obesity
  • Male
  • Humans
  • Female
  • Child
  • Chemical Physics
  • Case-Control Studies
  • Body Mass Index
  • Autonomic Nervous System
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Richer, L. P., Tan, Q., Butler, M. G., Avedzi, H. M., DeLorey, D. S., Peng, Y., … Haqq, A. M. (2023). Evaluation of Autonomic Nervous System Dysfunction in Childhood Obesity and Prader-Willi Syndrome. International Journal of Molecular Sciences, 24(9), 8013. https://doi.org/10.3390/ijms24098013
Richer, Lawrence P., Qiming Tan, Merlin G. Butler, Hayford M. Avedzi, Darren S. DeLorey, Ye Peng, Hein M. Tun, et al. “Evaluation of Autonomic Nervous System Dysfunction in Childhood Obesity and Prader-Willi Syndrome.International Journal of Molecular Sciences 24, no. 9 (April 2023): 8013. https://doi.org/10.3390/ijms24098013.
Richer LP, Tan Q, Butler MG, Avedzi HM, DeLorey DS, Peng Y, et al. Evaluation of Autonomic Nervous System Dysfunction in Childhood Obesity and Prader-Willi Syndrome. International Journal of Molecular Sciences. 2023 Apr;24(9):8013.
Richer, Lawrence P., et al. “Evaluation of Autonomic Nervous System Dysfunction in Childhood Obesity and Prader-Willi Syndrome.International Journal of Molecular Sciences, vol. 24, no. 9, Apr. 2023, p. 8013. Epmc, doi:10.3390/ijms24098013.
Richer LP, Tan Q, Butler MG, Avedzi HM, DeLorey DS, Peng Y, Tun HM, Sharma AM, Ainsley S, Orsso CE, Triador L, Freemark M, Haqq AM. Evaluation of Autonomic Nervous System Dysfunction in Childhood Obesity and Prader-Willi Syndrome. International Journal of Molecular Sciences. 2023 Apr;24(9):8013.

Published In

International Journal of Molecular Sciences

DOI

EISSN

1422-0067

ISSN

1422-0067

Publication Date

April 2023

Volume

24

Issue

9

Start / End Page

8013

Related Subject Headings

  • Prader-Willi Syndrome
  • Pediatric Obesity
  • Male
  • Humans
  • Female
  • Child
  • Chemical Physics
  • Case-Control Studies
  • Body Mass Index
  • Autonomic Nervous System