Leveraging preclinical study designs to close gaps in vaccine development for perinatal pathogens.

Vaccines to perinatal pathogens are critical for both reducing the burden of endemic pathogens and preparing for the next pandemic. Although they are often at greater risk of severe disease from infection, pregnant people and children are routinely marginalized in the vaccine development process. We highlight several challenges in the vaccine development process and how three tools-translational animal models, human cohort studies of natural infection, and innovative data-use strategies-can speed vaccine development and ensure equity for pregnant people and children in the next pandemic.

Duke Scholars

Author Chi Wei Cliburn Chan Biostatistics & Bioinformatics, Division of Integrative Geno ...

Author Sallie Robey Permar Pathology