Supplementary Figure S2 from Epidermal growth factor receptor inhibition by cetuximab modulates hypoxia and interferon response genes in head and neck squamous cell carcinoma
Chaudhary, R; Slebos, RJC; Noel, LC; Song, F; Poole, MI; Hoening, DS; Hernandez-Prera, JC; Conejo-Garcia, JR; Guevara, JA; Wang, X; Xie, M ...
<p>(A, B) Representative mIHC images showing staining of nuclei (blue), tumor cell (orange - PCK) and selected immune checkpoint markers in each molecular subgroup. (A) Images show four lymphoid markers - CD3+ T-cells (Green), CD8+ cytotoxic T-cells (Yellow), CD69+ activated T-cells (Red) and CD103+ resident memory T-cells (Cyan). (B) Images show three myeloid markers – HLA-DR+ APCs (Green), MHCII+ APCs (Cyan) and CD163+ M2 macrophages (Yellow).
(C) Linear model showing correlation between PD-L1 CPS and Immune, Mixture and Hypoxia subgroups.
(D-E) Boxplots showing cell counts distribution of different immune markers among the primary (n = 63) and recurrent (n = 20) tumors in TMA mIHC cohort. Students t-tests were used to test for significant differences between the groups.
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