A genome-wide and cotranscriptional suppressor of R loops.
Publication
, Journal Article
Matson, JP; Zou, L
Published in: Genes Dev
July 1, 2020
R loops arise from hybridization of RNA transcripts with template DNA during transcription. Unrepaired R loops lead to transcription-replication collisions, causing DNA damage and genomic instability. In this issue of Genes & Development, Pérez-Calero and colleagues (pp. 898-912) identify UAP56 as a cotranscriptional RNA-DNA helicase that unwinds R loops. They found that UAP56 helicase activity is required to remove R loops formed from different sources and prevent R-loop accumulation genome-wide at actively transcribed genes.
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Published In
Genes Dev
DOI
EISSN
1549-5477
Publication Date
July 1, 2020
Volume
34
Issue
13-14
Start / End Page
863 / 864
Location
United States
Related Subject Headings
- Transcription, Genetic
- R-Loop Structures
- K562 Cells
- Humans
- Genomic Instability
- Genome
- Developmental Biology
- DEAD-box RNA Helicases
- Chromatin
- 52 Psychology
Citation
APA
Chicago
ICMJE
MLA
NLM
Matson, J. P., & Zou, L. (2020). A genome-wide and cotranscriptional suppressor of R loops. Genes Dev, 34(13–14), 863–864. https://doi.org/10.1101/gad.339861.120
Matson, Jacob P., and Lee Zou. “A genome-wide and cotranscriptional suppressor of R loops.” Genes Dev 34, no. 13–14 (July 1, 2020): 863–64. https://doi.org/10.1101/gad.339861.120.
Matson JP, Zou L. A genome-wide and cotranscriptional suppressor of R loops. Genes Dev. 2020 Jul 1;34(13–14):863–4.
Matson, Jacob P., and Lee Zou. “A genome-wide and cotranscriptional suppressor of R loops.” Genes Dev, vol. 34, no. 13–14, July 2020, pp. 863–64. Pubmed, doi:10.1101/gad.339861.120.
Matson JP, Zou L. A genome-wide and cotranscriptional suppressor of R loops. Genes Dev. 2020 Jul 1;34(13–14):863–864.
Published In
Genes Dev
DOI
EISSN
1549-5477
Publication Date
July 1, 2020
Volume
34
Issue
13-14
Start / End Page
863 / 864
Location
United States
Related Subject Headings
- Transcription, Genetic
- R-Loop Structures
- K562 Cells
- Humans
- Genomic Instability
- Genome
- Developmental Biology
- DEAD-box RNA Helicases
- Chromatin
- 52 Psychology