Induction of BRCAness in Triple-Negative Breast Cancer by a CDK12/13 Inhibitor Improves Chemotherapy.
Publication
, Journal Article
Hopkins, JL; Zou, L
Published in: Cancer Cell
November 11, 2019
In this issue of Cancer Cell, Quereda and colleagues report that a newly developed specific inhibitor of CDK12/13, SR-4835, sensitizes triple-negative breast cancer cells to PARP inhibitors and DNA-damaging chemotherapeutics by reducing expression of the genes in the DNA damage response pathway.
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Published In
Cancer Cell
DOI
EISSN
1878-3686
Publication Date
November 11, 2019
Volume
36
Issue
5
Start / End Page
461 / 463
Location
United States
Related Subject Headings
- Triple Negative Breast Neoplasms
- Poly(ADP-ribose) Polymerase Inhibitors
- Oncology & Carcinogenesis
- Humans
- DNA Damage
- Cyclin-Dependent Kinases
- CDC2 Protein Kinase
- 3211 Oncology and carcinogenesis
- 3101 Biochemistry and cell biology
- 1112 Oncology and Carcinogenesis
Citation
APA
Chicago
ICMJE
MLA
NLM
Hopkins, J. L., & Zou, L. (2019). Induction of BRCAness in Triple-Negative Breast Cancer by a CDK12/13 Inhibitor Improves Chemotherapy. Cancer Cell, 36(5), 461–463. https://doi.org/10.1016/j.ccell.2019.10.012
Hopkins, Jessica L., and Lee Zou. “Induction of BRCAness in Triple-Negative Breast Cancer by a CDK12/13 Inhibitor Improves Chemotherapy.” Cancer Cell 36, no. 5 (November 11, 2019): 461–63. https://doi.org/10.1016/j.ccell.2019.10.012.
Hopkins JL, Zou L. Induction of BRCAness in Triple-Negative Breast Cancer by a CDK12/13 Inhibitor Improves Chemotherapy. Cancer Cell. 2019 Nov 11;36(5):461–3.
Hopkins, Jessica L., and Lee Zou. “Induction of BRCAness in Triple-Negative Breast Cancer by a CDK12/13 Inhibitor Improves Chemotherapy.” Cancer Cell, vol. 36, no. 5, Nov. 2019, pp. 461–63. Pubmed, doi:10.1016/j.ccell.2019.10.012.
Hopkins JL, Zou L. Induction of BRCAness in Triple-Negative Breast Cancer by a CDK12/13 Inhibitor Improves Chemotherapy. Cancer Cell. 2019 Nov 11;36(5):461–463.
Published In
Cancer Cell
DOI
EISSN
1878-3686
Publication Date
November 11, 2019
Volume
36
Issue
5
Start / End Page
461 / 463
Location
United States
Related Subject Headings
- Triple Negative Breast Neoplasms
- Poly(ADP-ribose) Polymerase Inhibitors
- Oncology & Carcinogenesis
- Humans
- DNA Damage
- Cyclin-Dependent Kinases
- CDC2 Protein Kinase
- 3211 Oncology and carcinogenesis
- 3101 Biochemistry and cell biology
- 1112 Oncology and Carcinogenesis