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Calcium Influx Guards Replication Forks against Exonuclease 1.

Publication ,  Journal Article
Simoneau, A; Zou, L
Published in: Mol Cell
June 20, 2019

In this issue, Li et al. (2019) report a previously unknown Ca2+-CaMKK2-AMPK signaling cascade that protects stalled forks from degradation by phosphorylating and inhibiting the EXO1 nuclease, revealing a surprising role for Ca2+ influx in the maintenance of genomic stability.

Duke Scholars

Published In

Mol Cell

DOI

EISSN

1097-4164

Publication Date

June 20, 2019

Volume

74

Issue

6

Start / End Page

1103 / 1105

Location

United States

Related Subject Headings

  • Phosphorylation
  • Exodeoxyribonucleases
  • Developmental Biology
  • DNA Replication
  • Calcium
  • AMP-Activated Protein Kinases
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
  • 11 Medical and Health Sciences
 

Citation

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Simoneau, A., & Zou, L. (2019). Calcium Influx Guards Replication Forks against Exonuclease 1. Mol Cell, 74(6), 1103–1105. https://doi.org/10.1016/j.molcel.2019.06.005
Simoneau, Antoine, and Lee Zou. “Calcium Influx Guards Replication Forks against Exonuclease 1.Mol Cell 74, no. 6 (June 20, 2019): 1103–5. https://doi.org/10.1016/j.molcel.2019.06.005.
Simoneau A, Zou L. Calcium Influx Guards Replication Forks against Exonuclease 1. Mol Cell. 2019 Jun 20;74(6):1103–5.
Simoneau, Antoine, and Lee Zou. “Calcium Influx Guards Replication Forks against Exonuclease 1.Mol Cell, vol. 74, no. 6, June 2019, pp. 1103–05. Pubmed, doi:10.1016/j.molcel.2019.06.005.
Simoneau A, Zou L. Calcium Influx Guards Replication Forks against Exonuclease 1. Mol Cell. 2019 Jun 20;74(6):1103–1105.
Journal cover image

Published In

Mol Cell

DOI

EISSN

1097-4164

Publication Date

June 20, 2019

Volume

74

Issue

6

Start / End Page

1103 / 1105

Location

United States

Related Subject Headings

  • Phosphorylation
  • Exodeoxyribonucleases
  • Developmental Biology
  • DNA Replication
  • Calcium
  • AMP-Activated Protein Kinases
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
  • 11 Medical and Health Sciences