A Zygotic Checkpoint for Unrepaired Lesions.
Publication
, Journal Article
Zou, L
Published in: Cell
December 15, 2016
DNA demethylation, a process involving DNA repair, is critical for reprogramming of the paternal genome during the oocyte-to-zygote transition. A new study by Ladstätter and Tachibana-Konwalski shows that a Chk1-mediated zygotic checkpoint monitors the cohesin-dependent repair of DNA lesions arising from DNA demethylation, which prevents zygotes carrying unrepaired lesions from entering mitosis.
Duke Scholars
Published In
Cell
DOI
EISSN
1097-4172
Publication Date
December 15, 2016
Volume
167
Issue
7
Start / End Page
1676 / 1678
Location
United States
Related Subject Headings
- Zygote
- Humans
- Genome
- Developmental Biology
- DNA Repair
- DNA Methylation
- Cell Cycle Checkpoints
- 32 Biomedical and clinical sciences
- 31 Biological sciences
- 11 Medical and Health Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Zou, L. (2016). A Zygotic Checkpoint for Unrepaired Lesions. Cell, 167(7), 1676–1678. https://doi.org/10.1016/j.cell.2016.11.049
Zou, Lee. “A Zygotic Checkpoint for Unrepaired Lesions.” Cell 167, no. 7 (December 15, 2016): 1676–78. https://doi.org/10.1016/j.cell.2016.11.049.
Zou L. A Zygotic Checkpoint for Unrepaired Lesions. Cell. 2016 Dec 15;167(7):1676–8.
Zou, Lee. “A Zygotic Checkpoint for Unrepaired Lesions.” Cell, vol. 167, no. 7, Dec. 2016, pp. 1676–78. Pubmed, doi:10.1016/j.cell.2016.11.049.
Zou L. A Zygotic Checkpoint for Unrepaired Lesions. Cell. 2016 Dec 15;167(7):1676–1678.
Published In
Cell
DOI
EISSN
1097-4172
Publication Date
December 15, 2016
Volume
167
Issue
7
Start / End Page
1676 / 1678
Location
United States
Related Subject Headings
- Zygote
- Humans
- Genome
- Developmental Biology
- DNA Repair
- DNA Methylation
- Cell Cycle Checkpoints
- 32 Biomedical and clinical sciences
- 31 Biological sciences
- 11 Medical and Health Sciences