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Genetic associations with parental investment from conception to wealth inheritance in six cohorts.

Publication ,  Journal Article
Wertz, J; Moffitt, TE; Arseneault, L; Barnes, JC; Boivin, M; Corcoran, DL; Danese, A; Hancox, RJ; Harrington, H; Houts, RM; Langevin, S ...
Published in: Nature human behaviour
August 2023

Genetic inheritance is not the only way parents' genes may affect children. It is also possible that parents' genes are associated with investments into children's development. We examined evidence for links between parental genetics and parental investments, from the prenatal period through to adulthood, using data from six population-based cohorts in the UK, US and New Zealand, together totalling 36,566 parents. Our findings revealed associations between parental genetics-summarized in a genome-wide polygenic score-and parental behaviour across development, from smoking in pregnancy, breastfeeding in infancy, parenting in childhood and adolescence, to leaving a wealth inheritance to adult children. Effect sizes tended to be small at any given time point, ranging from RR = 1.12 (95% confidence interval (95%CI) 1.09, 1.15) to RR = 0.76 (95%CI 0.72, 0.80) during the prenatal period and infancy; β = 0.07 (95%CI 0.04, 0.11) to β = 0.29 (95%CI 0.27, 0.32) in childhood and adolescence, and RR = 1.04 (95%CI 1.01, 1.06) to RR = 1.11 (95%CI 1.07, 1.15) in adulthood. There was evidence for accumulating effects across development, ranging from β = 0.15 (95%CI 0.11, 0.18) to β = 0.23 (95%CI 0.16, 0.29) depending on cohort. Our findings are consistent with the interpretation that parents pass on advantages to offspring not only via direct genetic transmission or purely environmental paths, but also via genetic associations with parental investment from conception to wealth inheritance.

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Published In

Nature human behaviour

DOI

EISSN

2397-3374

ISSN

2397-3374

Publication Date

August 2023

Volume

7

Issue

8

Start / End Page

1388 / 1401

Related Subject Headings

  • Smoking
  • Pregnancy
  • Parents
  • Parenting
  • New Zealand
  • Humans
  • Female
  • Adult
  • Adolescent
  • 52 Psychology
 

Citation

APA
Chicago
ICMJE
MLA
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Wertz, J., Moffitt, T. E., Arseneault, L., Barnes, J. C., Boivin, M., Corcoran, D. L., … Caspi, A. (2023). Genetic associations with parental investment from conception to wealth inheritance in six cohorts. Nature Human Behaviour, 7(8), 1388–1401. https://doi.org/10.1038/s41562-023-01618-5
Wertz, Jasmin, Terrie E. Moffitt, Louise Arseneault, J. C. Barnes, Michel Boivin, David L. Corcoran, Andrea Danese, et al. “Genetic associations with parental investment from conception to wealth inheritance in six cohorts.Nature Human Behaviour 7, no. 8 (August 2023): 1388–1401. https://doi.org/10.1038/s41562-023-01618-5.
Wertz J, Moffitt TE, Arseneault L, Barnes JC, Boivin M, Corcoran DL, et al. Genetic associations with parental investment from conception to wealth inheritance in six cohorts. Nature human behaviour. 2023 Aug;7(8):1388–401.
Wertz, Jasmin, et al. “Genetic associations with parental investment from conception to wealth inheritance in six cohorts.Nature Human Behaviour, vol. 7, no. 8, Aug. 2023, pp. 1388–401. Epmc, doi:10.1038/s41562-023-01618-5.
Wertz J, Moffitt TE, Arseneault L, Barnes JC, Boivin M, Corcoran DL, Danese A, Hancox RJ, Harrington H, Houts RM, Langevin S, Liu H, Poulton R, Sugden K, Tanksley PT, Williams BS, Caspi A. Genetic associations with parental investment from conception to wealth inheritance in six cohorts. Nature human behaviour. 2023 Aug;7(8):1388–1401.

Published In

Nature human behaviour

DOI

EISSN

2397-3374

ISSN

2397-3374

Publication Date

August 2023

Volume

7

Issue

8

Start / End Page

1388 / 1401

Related Subject Headings

  • Smoking
  • Pregnancy
  • Parents
  • Parenting
  • New Zealand
  • Humans
  • Female
  • Adult
  • Adolescent
  • 52 Psychology