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Utility of triazole antifungal therapeutic drug monitoring: Insights from the Society of Infectious Diseases Pharmacists: Endorsed by the Mycoses Study Group Education and Research Consortium.

Publication ,  Journal Article
McCreary, EK; Davis, MR; Narayanan, N; Andes, DR; Cattaneo, D; Christian, R; Lewis, RE; Watt, KM; Wiederhold, NP; Johnson, MD
Published in: Pharmacotherapy
October 2023

Triazole antifungals (i.e., fluconazole, itraconazole, voriconazole, posaconazole, and isavuconazole) are commonly used in clinical practice to prevent or treat invasive fungal infections. Most triazole antifungals require therapeutic drug monitoring (TDM) due to highly variable pharmacokinetics, known drug interactions, and established relationships between exposure and response. On behalf of the Society of Infectious Diseases Pharmacists (SIDP), this insight describes the pharmacokinetic principles and pharmacodynamic targets of commonly used triazole antifungals and provides the rationale for utility of TDM within each agent.

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Published In

Pharmacotherapy

DOI

EISSN

1875-9114

Publication Date

October 2023

Volume

43

Issue

10

Start / End Page

1043 / 1050

Location

United States

Related Subject Headings

  • Voriconazole
  • Triazoles
  • Pharmacology & Pharmacy
  • Pharmacists
  • Mycoses
  • Humans
  • Drug Monitoring
  • Communicable Diseases
  • Antifungal Agents
  • 3214 Pharmacology and pharmaceutical sciences
 

Citation

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McCreary, E. K., Davis, M. R., Narayanan, N., Andes, D. R., Cattaneo, D., Christian, R., … Johnson, M. D. (2023). Utility of triazole antifungal therapeutic drug monitoring: Insights from the Society of Infectious Diseases Pharmacists: Endorsed by the Mycoses Study Group Education and Research Consortium. Pharmacotherapy, 43(10), 1043–1050. https://doi.org/10.1002/phar.2850
McCreary, Erin K., Matthew R. Davis, Navaneeth Narayanan, David R. Andes, Dario Cattaneo, Robbie Christian, Russell E. Lewis, Kevin M. Watt, Nathan P. Wiederhold, and Melissa D. Johnson. “Utility of triazole antifungal therapeutic drug monitoring: Insights from the Society of Infectious Diseases Pharmacists: Endorsed by the Mycoses Study Group Education and Research Consortium.Pharmacotherapy 43, no. 10 (October 2023): 1043–50. https://doi.org/10.1002/phar.2850.
McCreary EK, Davis MR, Narayanan N, Andes DR, Cattaneo D, Christian R, Lewis RE, Watt KM, Wiederhold NP, Johnson MD. Utility of triazole antifungal therapeutic drug monitoring: Insights from the Society of Infectious Diseases Pharmacists: Endorsed by the Mycoses Study Group Education and Research Consortium. Pharmacotherapy. 2023 Oct;43(10):1043–1050.
Journal cover image

Published In

Pharmacotherapy

DOI

EISSN

1875-9114

Publication Date

October 2023

Volume

43

Issue

10

Start / End Page

1043 / 1050

Location

United States

Related Subject Headings

  • Voriconazole
  • Triazoles
  • Pharmacology & Pharmacy
  • Pharmacists
  • Mycoses
  • Humans
  • Drug Monitoring
  • Communicable Diseases
  • Antifungal Agents
  • 3214 Pharmacology and pharmaceutical sciences