Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel

Lifetime Incidence of Treated Mental Health Disorders and Psychotropic Drug Prescriptions and Associated Socioeconomic Functioning.

Publication ,  Journal Article
Kessing, LV; Ziersen, SC; Caspi, A; Moffitt, TE; Andersen, PK
Published in: JAMA psychiatry
October 2023

Few studies have estimated the lifetime incidence of mental health disorders and the association with socioeconomic functioning.To investigate whether the lifetime incidence of treated mental health disorders is substantially higher than previously reported and estimate associations with long-term socioeconomic difficulties.This nationwide population-based register linkage study includes a randomly selected sample of 1.5 million individuals from the population of Denmark from 1995 to 2018. Data were analyzed from May 2022 to March 2023.Lifetime incidence of any treated mental health disorder in the general population was estimated from birth to age 100 years taking into account the competing risk of all-cause death and associations with socioeconomic functioning. Register measures were (1) from hospitals, a diagnosis of any mental health disorder at an inpatient/outpatient hospital contact; (2) from hospitals and prescription statistics, any mental health disorder/psychotropic prescription, including a hospital-contact diagnosis, or any psychotropic medication prescribed by physicians, including general practitioners or private psychiatrists; and (3) socioeconomic functioning as indicated by highest educational achievement, employment, income, residential status, and marital status.Among a sample of 462 864 individuals with any mental health disorder, the median (IQR) age was 36.6 years (21.0-53.6 years), 233 747 (50.5%) were male, and 229 117 (49.5%) were female. Of these, 112 641 were registered with a hospital-contact mental health disorder diagnosis and 422 080 with a prescription of psychotropic medication. The cumulative incidence of a hospital-contact mental health disorder diagnosis was 29.0% (95% CI, 28.8-29.1), 31.8% (95% CI, 31.6-32.0) for females, and 26.1% (95% CI, 25.9-26.3) for males. When also considering psychotropic prescriptions, the cumulative incidence of any mental health disorder/psychotropic prescription was 82.6% (95% CI, 82.4-82.6), 87.5% (95% CI, 87.4-87.7) for females, and 76.7% (95% CI, 76.5-76.8) for males. Socioeconomic difficulties were associated with mental health disorder/psychotropic prescriptions, including lower income (hazard ratio [HR], 1.55; 95% CI, 1.53-1.56), increased unemployment or disability benefit (HR, 2.50; 95% CI, 2.47-2.53), and a greater likelihood of living alone (HR, 1.78; 95% CI, 1.76-1.80) and being unmarried (HR, 2.02; 95% CI, 2.01-2.04) during long-term follow-up. These rates were confirmed in 4 sensitivity analyses with the lowest being 74.8% (95% CI, 74.7-75.0) (1) by using varying exclusion periods, (2) by excluding prescriptions of anxiolytics and quetiapine that may be used for off-label indications, (3) by defining any mental health disorder/psychotropic prescription as any hospital-contact mental health disorder diagnosis or any psychotropic medication prescribed at least 2 times, and (4) by excluding individuals with somatic diagnoses for which psychotropics may be prescribed off-label.This registry study of data from a large representative sample of the Danish population showed that the majority of individuals either received a diagnosis of a mental health disorder or were prescribed psychotropic medication during their lifetime, which was associated with subsequent socioeconomic difficulties. These findings may help change our understanding of normalcy and mental illness, reduce stigmatization, and further prompt rethinking the primary prevention of mental illness and future mental health clinical resources.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

JAMA psychiatry

DOI

EISSN

2168-6238

ISSN

2168-622X

Publication Date

October 2023

Volume

80

Issue

10

Start / End Page

1000 / 1008

Related Subject Headings

  • 5203 Clinical and health psychology
  • 3202 Clinical sciences
  • 1702 Cognitive Sciences
  • 1701 Psychology
  • 1199 Other Medical and Health Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kessing, L. V., Ziersen, S. C., Caspi, A., Moffitt, T. E., & Andersen, P. K. (2023). Lifetime Incidence of Treated Mental Health Disorders and Psychotropic Drug Prescriptions and Associated Socioeconomic Functioning. JAMA Psychiatry, 80(10), 1000–1008. https://doi.org/10.1001/jamapsychiatry.2023.2206
Kessing, Lars Vedel, Simon Christoffer Ziersen, Avshalom Caspi, Terrie E. Moffitt, and Per Kragh Andersen. “Lifetime Incidence of Treated Mental Health Disorders and Psychotropic Drug Prescriptions and Associated Socioeconomic Functioning.JAMA Psychiatry 80, no. 10 (October 2023): 1000–1008. https://doi.org/10.1001/jamapsychiatry.2023.2206.
Kessing LV, Ziersen SC, Caspi A, Moffitt TE, Andersen PK. Lifetime Incidence of Treated Mental Health Disorders and Psychotropic Drug Prescriptions and Associated Socioeconomic Functioning. JAMA psychiatry. 2023 Oct;80(10):1000–8.
Kessing, Lars Vedel, et al. “Lifetime Incidence of Treated Mental Health Disorders and Psychotropic Drug Prescriptions and Associated Socioeconomic Functioning.JAMA Psychiatry, vol. 80, no. 10, Oct. 2023, pp. 1000–08. Epmc, doi:10.1001/jamapsychiatry.2023.2206.
Kessing LV, Ziersen SC, Caspi A, Moffitt TE, Andersen PK. Lifetime Incidence of Treated Mental Health Disorders and Psychotropic Drug Prescriptions and Associated Socioeconomic Functioning. JAMA psychiatry. 2023 Oct;80(10):1000–1008.

Published In

JAMA psychiatry

DOI

EISSN

2168-6238

ISSN

2168-622X

Publication Date

October 2023

Volume

80

Issue

10

Start / End Page

1000 / 1008

Related Subject Headings

  • 5203 Clinical and health psychology
  • 3202 Clinical sciences
  • 1702 Cognitive Sciences
  • 1701 Psychology
  • 1199 Other Medical and Health Sciences