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Smoking reduction using electronic nicotine delivery systems in combination with nicotine skin patches.

Publication ,  Journal Article
Rose, JE; Frisbee, S; Campbell, D; Salley, A; Claerhout, S; Davis, JM
Published in: Psychopharmacology (Berl)
September 2023

RATIONALE: Electronic nicotine delivery systems (ENDS) are used by smokers seeking to reduce combustible cigarette (CC) use, but the role of nicotine replacement vs. behavioral and sensory factors is still poorly understood. We hypothesized that providing nicotine from ENDS in addition to nicotine skin patches would promote smoking reduction relative to non-nicotine control ENDS. OBJECTIVES: To assess the effects on smoking behavior of using nicotine vs. placebo ENDS in smokers using nicotine vs. placebo patches. METHODS: Ninety-four daily smokers were enrolled in a study that randomly assigned them to receive ENDS with nicotine vs. without nicotine and skin patches with vs. without nicotine. Smoking reduction and cessation were assessed over an 8-week period by self-report and by expired air carbon monoxide (CO) measurements. The primary outcome was defined as reduction in expired air CO. RESULTS: The use of nicotine in ENDS led to significant reductions in smoking (ENDS nicotine vs. placebo difference in CO change = -9.2 ppm; 90% CI (-1.5 ppm, -16.9 ppm)) and was highly correlated with reductions in self-reported cigarettes per day (r=0.6). The effect of nicotine in nicotine patches was not statistically significant (patch nicotine vs. placebo difference in CO change = -0.1 ppm; 90% CI (-7.8 ppm, 7.6 ppm)). CONCLUSIONS: The presence of nicotine in ENDS was associated with a large reduction in smoking. Additional studies will be needed to determine whether there may be additive effects of nicotine ENDS and nicotine patches on smoking abstinence.

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Published In

Psychopharmacology (Berl)

DOI

EISSN

1432-2072

Publication Date

September 2023

Volume

240

Issue

9

Start / End Page

1901 / 1909

Location

Germany

Related Subject Headings

  • Tobacco Use Cessation Devices
  • Smoking Reduction
  • Smoking Cessation
  • Psychiatry
  • Nicotine
  • Humans
  • Electronic Nicotine Delivery Systems
  • 5202 Biological psychology
  • 17 Psychology and Cognitive Sciences
  • 11 Medical and Health Sciences
 

Citation

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Rose, J. E., Frisbee, S., Campbell, D., Salley, A., Claerhout, S., & Davis, J. M. (2023). Smoking reduction using electronic nicotine delivery systems in combination with nicotine skin patches. Psychopharmacology (Berl), 240(9), 1901–1909. https://doi.org/10.1007/s00213-023-06401-y
Rose, Jed E., Suzanne Frisbee, David Campbell, Alfred Salley, Susan Claerhout, and James M. Davis. “Smoking reduction using electronic nicotine delivery systems in combination with nicotine skin patches.Psychopharmacology (Berl) 240, no. 9 (September 2023): 1901–9. https://doi.org/10.1007/s00213-023-06401-y.
Rose JE, Frisbee S, Campbell D, Salley A, Claerhout S, Davis JM. Smoking reduction using electronic nicotine delivery systems in combination with nicotine skin patches. Psychopharmacology (Berl). 2023 Sep;240(9):1901–9.
Rose, Jed E., et al. “Smoking reduction using electronic nicotine delivery systems in combination with nicotine skin patches.Psychopharmacology (Berl), vol. 240, no. 9, Sept. 2023, pp. 1901–09. Pubmed, doi:10.1007/s00213-023-06401-y.
Rose JE, Frisbee S, Campbell D, Salley A, Claerhout S, Davis JM. Smoking reduction using electronic nicotine delivery systems in combination with nicotine skin patches. Psychopharmacology (Berl). 2023 Sep;240(9):1901–1909.
Journal cover image

Published In

Psychopharmacology (Berl)

DOI

EISSN

1432-2072

Publication Date

September 2023

Volume

240

Issue

9

Start / End Page

1901 / 1909

Location

Germany

Related Subject Headings

  • Tobacco Use Cessation Devices
  • Smoking Reduction
  • Smoking Cessation
  • Psychiatry
  • Nicotine
  • Humans
  • Electronic Nicotine Delivery Systems
  • 5202 Biological psychology
  • 17 Psychology and Cognitive Sciences
  • 11 Medical and Health Sciences