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Microglia Preserve Visual Function in a Mouse Model of Retinitis Pigmentosa with Rhodopsin-P23H Mutant.

Publication ,  Journal Article
Yu, C; Saban, DR
Published in: Adv Exp Med Biol
2023

Most forms of outer retinal degenerative diseases involve the ectopic accumulation of microglia/macrophages in the subretinal space, including retinitis pigmentosa. However, their role in the loss of photoreceptor function during retinal degeneration remains unknown. Here, we examined the effect of conditional microglial depletion on photoreceptor numbers and visual function in mice with the rhodopsin P23H mutation, a dominant form of retinitis pigmentosa in humans. We found that microglial depletion led to an elevated level of rhodopsin and increased photoreceptor layer thickness. However, overall electrophysiological functions of the retina were reduced with microglial depletion. Therefore, these results identify an essential role of microglia specially in preserving visual function in outer retinal degeneration.

Duke Scholars

Published In

Adv Exp Med Biol

DOI

ISSN

0065-2598

Publication Date

2023

Volume

1415

Start / End Page

421 / 425

Location

United States

Related Subject Headings

  • Rhodopsin
  • Retinitis Pigmentosa
  • Retinal Degeneration
  • Retina
  • Microglia
  • Mice
  • Humans
  • General & Internal Medicine
  • Disease Models, Animal
  • Animals
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Yu, C., & Saban, D. R. (2023). Microglia Preserve Visual Function in a Mouse Model of Retinitis Pigmentosa with Rhodopsin-P23H Mutant. Adv Exp Med Biol, 1415, 421–425. https://doi.org/10.1007/978-3-031-27681-1_62
Yu, Chen, and Daniel R. Saban. “Microglia Preserve Visual Function in a Mouse Model of Retinitis Pigmentosa with Rhodopsin-P23H Mutant.Adv Exp Med Biol 1415 (2023): 421–25. https://doi.org/10.1007/978-3-031-27681-1_62.
Yu, Chen, and Daniel R. Saban. “Microglia Preserve Visual Function in a Mouse Model of Retinitis Pigmentosa with Rhodopsin-P23H Mutant.Adv Exp Med Biol, vol. 1415, 2023, pp. 421–25. Pubmed, doi:10.1007/978-3-031-27681-1_62.

Published In

Adv Exp Med Biol

DOI

ISSN

0065-2598

Publication Date

2023

Volume

1415

Start / End Page

421 / 425

Location

United States

Related Subject Headings

  • Rhodopsin
  • Retinitis Pigmentosa
  • Retinal Degeneration
  • Retina
  • Microglia
  • Mice
  • Humans
  • General & Internal Medicine
  • Disease Models, Animal
  • Animals