Skip to main content

SDF-1 Bound Heparin Nanoparticles Recruit Progenitor Cells for Their Differentiation and Promotion of Angiogenesis After Stroke.

Publication ,  Journal Article
Wilson, KL; Onweller, LA; Joseph, NI; David-Bercholz, J; Darling, NJ; Segura, T
Published in: bioRxiv
July 5, 2023

Angiogenesis after stroke is correlated with enhanced tissue repair and functional outcomes. The existing body of research in biomaterials for stroke focuses on hydrogels for the delivery of stem cells, growth factors, or small molecules or drugs. Despite the ability of hydrogels to enhance all these delivery methods, no material has significantly regrown vasculature within the translatable timeline of days to weeks after stroke. Here we developed 2 novel biomaterials for tissue regeneration after stroke, a highly porous granular hydrogel termed Cryo microgels, and heparin-norbornene nanoparticles with covalently bound SDF-1α. The combination of these materials resulted in fully revascularized vessels throughout the stroke core in only 10 days, as well as increased neural progenitor cell migration and maintenance and increased neurons.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

bioRxiv

DOI

Publication Date

July 5, 2023

Location

United States
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wilson, K. L., Onweller, L. A., Joseph, N. I., David-Bercholz, J., Darling, N. J., & Segura, T. (2023). SDF-1 Bound Heparin Nanoparticles Recruit Progenitor Cells for Their Differentiation and Promotion of Angiogenesis After Stroke. BioRxiv. https://doi.org/10.1101/2023.07.05.547800
Wilson, Katrina L., Lauren A. Onweller, Neica I. Joseph, Jennifer David-Bercholz, Nicole J. Darling, and Tatiana Segura. “SDF-1 Bound Heparin Nanoparticles Recruit Progenitor Cells for Their Differentiation and Promotion of Angiogenesis After Stroke.BioRxiv, July 5, 2023. https://doi.org/10.1101/2023.07.05.547800.
Wilson KL, Onweller LA, Joseph NI, David-Bercholz J, Darling NJ, Segura T. SDF-1 Bound Heparin Nanoparticles Recruit Progenitor Cells for Their Differentiation and Promotion of Angiogenesis After Stroke. bioRxiv. 2023 Jul 5;
Wilson, Katrina L., et al. “SDF-1 Bound Heparin Nanoparticles Recruit Progenitor Cells for Their Differentiation and Promotion of Angiogenesis After Stroke.BioRxiv, July 2023. Pubmed, doi:10.1101/2023.07.05.547800.
Wilson KL, Onweller LA, Joseph NI, David-Bercholz J, Darling NJ, Segura T. SDF-1 Bound Heparin Nanoparticles Recruit Progenitor Cells for Their Differentiation and Promotion of Angiogenesis After Stroke. bioRxiv. 2023 Jul 5;

Published In

bioRxiv

DOI

Publication Date

July 5, 2023

Location

United States