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Concordance/discordance between serum apolipoprotein B, low density lipoprotein cholesterol and non-high density lipoprotein cholesterol in NATPOL 2011 participants - An epidemiological perspective.

Publication ,  Journal Article
Solnica, B; Sniderman, AD; Wyszomirski, A; Rutkowski, M; Chlebus, K; Bandosz, P; Pencina, MJ; Zdrojewski, T
Published in: Int J Cardiol
November 1, 2023

BACKGROUND: The study compared the distribution of serum LDL-C, non-HDL-C, and apolipoprotein B (apoB) among participants of the NATPOL 2011 survey and analysed concordance/discordance of results in the context of the risk for atherosclerotic cardiovascular disease (ASCVD). METHODS: Serum levels of apoB, LDL-C, non-HDL-C and small dense LDL-C were measured/calculated in 2067-2098 survey participants. The results were compared between women and men, age groups and in relation to body mass index (BMI), fasting glucose and TG levels, and the presence of CVD. Percentile distribution of lipid levels and concordance/discordance analysis were based on medians and ESC/EAS 2019 target thresholds for ASCVD risk and on comparison of measured apoB levels and levels calculated from linear regression equations with serum LDL- C and non-HDL-C as independent variables. RESULTS: Serum apoB, LDL-C and non-HDL-C were similarly related to sex, age, BMI, visceral obesity, cardiovascular disease, and fasting glucose and triglyceride levels. Serum apoB, LDL-C and non-HDL-C very high- and moderate- target thresholds were exceeded in 83%, 99% and 96.9% and in 41%, 75% and 63.7% of subjects, respectively. The incidence of the discordances between the results depended on the dividing values used and ranged from 0.2% to 45.2% of the respondents. Subjects with high apoB / low LDL-C/non-HDL-C discordance had features of metabolic syndrome. CONCLUSIONS: Diagnostic discordances between apoB and LDL-C/non-HDL-C indicate limitations of serum LDL-C/non-HDL-C in ASCVD risk management. Due to the high apoB/low LDL-C/non-HDL-C discordance, obese/metabolic syndrome patients may benefit from replacing LDL-C/non-HDL-C by apoB in ASCVD risk assessment and lipid-lowering therapy.

Duke Scholars

Published In

Int J Cardiol

DOI

EISSN

1874-1754

Publication Date

November 1, 2023

Volume

390

Start / End Page

131150

Location

Netherlands

Related Subject Headings

  • Metabolic Syndrome
  • Male
  • Humans
  • Female
  • Cholesterol, LDL
  • Cholesterol, HDL
  • Cardiovascular System & Hematology
  • Cardiovascular Diseases
  • Atherosclerosis
  • Apolipoproteins B
 

Citation

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Solnica, B., Sniderman, A. D., Wyszomirski, A., Rutkowski, M., Chlebus, K., Bandosz, P., … Zdrojewski, T. (2023). Concordance/discordance between serum apolipoprotein B, low density lipoprotein cholesterol and non-high density lipoprotein cholesterol in NATPOL 2011 participants - An epidemiological perspective. Int J Cardiol, 390, 131150. https://doi.org/10.1016/j.ijcard.2023.131150
Solnica, Bogdan, Allan D. Sniderman, Adam Wyszomirski, Marcin Rutkowski, Krzysztof Chlebus, Piotr Bandosz, Michael J. Pencina, and Tomasz Zdrojewski. “Concordance/discordance between serum apolipoprotein B, low density lipoprotein cholesterol and non-high density lipoprotein cholesterol in NATPOL 2011 participants - An epidemiological perspective.Int J Cardiol 390 (November 1, 2023): 131150. https://doi.org/10.1016/j.ijcard.2023.131150.
Solnica B, Sniderman AD, Wyszomirski A, Rutkowski M, Chlebus K, Bandosz P, Pencina MJ, Zdrojewski T. Concordance/discordance between serum apolipoprotein B, low density lipoprotein cholesterol and non-high density lipoprotein cholesterol in NATPOL 2011 participants - An epidemiological perspective. Int J Cardiol. 2023 Nov 1;390:131150.
Journal cover image

Published In

Int J Cardiol

DOI

EISSN

1874-1754

Publication Date

November 1, 2023

Volume

390

Start / End Page

131150

Location

Netherlands

Related Subject Headings

  • Metabolic Syndrome
  • Male
  • Humans
  • Female
  • Cholesterol, LDL
  • Cholesterol, HDL
  • Cardiovascular System & Hematology
  • Cardiovascular Diseases
  • Atherosclerosis
  • Apolipoproteins B