Scholars@Duke

Supplementary Figure Legends 1-7 from CBF-Beta Mitigates PI3K-Alpha–Specific Inhibitor Killing through PIM1 in <i>PIK3CA</i>-Mutant Gastric Cancer

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Stanland, LJ; Ang, HX; Hoj, JP; Chu, Y; Tan, P; Wood, KC; Luftig, MA
August 9, 2023
Published version (DOI) Publisher Link

<p>S1. BYL719 and DMSO beta scores S2. Ribbon plots of non-gastric cancer cell lines included in screen. S3. Dasatinib renders AGS cells hyper-sensitive to BYL719 S4. Loss of BCL-XL induces cell death in BYL719 treated MKN1 S5. BCL-XL inhibitor A-1331852 is the only inhibitor capable of increasing BYL719-induced cell death and inhibiting cell growth. S6. CBFB binding co-factor RUNX1 is down-regulated at protein and mRNA level in BYL719 resistant clones. S7. Pan-PIM inhibition or PIM1 KO re-sensitizes CBFB KO and resistant clones to BYL719.</p>

Duke Scholars

Micah Alan Luftig
Author Micah Alan Luftig Molecular Genetics and Microbiology
Kris Cameron Wood
Author Kris Cameron Wood Pharmacology & Cancer Biology

DOI

10.1158/1541-7786.23912456

Publication Date

August 9, 2023
 

Citation

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Stanland, L. J., Ang, H. X., Hoj, J. P., Chu, Y., Tan, P., Wood, K. C., & Luftig, M. A. (2023). Supplementary Figure Legends 1-7 from CBF-Beta Mitigates PI3K-Alpha–Specific Inhibitor Killing through PIM1 in <i>PIK3CA</i>-Mutant Gastric Cancer. https://doi.org/10.1158/1541-7786.23912456
Stanland, Lyla J., Hazel X. Ang, Jacob P. Hoj, Yunqiang Chu, Patrick Tan, Kris C. Wood, and Micah A. Luftig. “Supplementary Figure Legends 1-7 from CBF-Beta Mitigates PI3K-Alpha–Specific Inhibitor Killing through PIM1 in <i>PIK3CA</i>-Mutant Gastric Cancer,” August 9, 2023. https://doi.org/10.1158/1541-7786.23912456.

DOI

10.1158/1541-7786.23912456

Publication Date

August 9, 2023