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Deciphering and targeting host factors to counteract SARS-CoV-2 and coronavirus infections: insights from CRISPR approaches.

Publication ,  Journal Article
Cui, Z; Wang, H; Dong, Y; Liu, S-L; Wang, Q
Published in: Front Genome Ed
2023

Severe respiratory syndrome coronavirus 2 (SARS-CoV-2) and other coronaviruses depend on host factors for the process of viral infection and replication. A better understanding of the dynamic interplay between viral pathogens and host cells, as well as identifying of virus-host dependencies, offers valuable insights into disease mechanisms and informs the development of effective therapeutic strategies against viral infections. This review delves into the key host factors that facilitate or hinder SARS-CoV-2 infection and replication, as identified by CRISPR/Cas9-based screening platforms. Furthermore, we explore CRISPR/Cas13-based gene therapy strategies aimed at targeting these host factors to inhibit viral infection, with the ultimate goal of eradicating SARS-CoV-2 and preventing and treating related coronaviruses for future outbreaks.

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Published In

Front Genome Ed

DOI

EISSN

2673-3439

Publication Date

2023

Volume

5

Start / End Page

1231656

Location

Switzerland
 

Citation

APA
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ICMJE
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Cui, Z., Wang, H., Dong, Y., Liu, S.-L., & Wang, Q. (2023). Deciphering and targeting host factors to counteract SARS-CoV-2 and coronavirus infections: insights from CRISPR approaches. Front Genome Ed, 5, 1231656. https://doi.org/10.3389/fgeed.2023.1231656
Cui, Zhifen, Hongyan Wang, Yizhou Dong, Shan-Lu Liu, and Qianben Wang. “Deciphering and targeting host factors to counteract SARS-CoV-2 and coronavirus infections: insights from CRISPR approaches.Front Genome Ed 5 (2023): 1231656. https://doi.org/10.3389/fgeed.2023.1231656.
Cui, Zhifen, et al. “Deciphering and targeting host factors to counteract SARS-CoV-2 and coronavirus infections: insights from CRISPR approaches.Front Genome Ed, vol. 5, 2023, p. 1231656. Pubmed, doi:10.3389/fgeed.2023.1231656.

Published In

Front Genome Ed

DOI

EISSN

2673-3439

Publication Date

2023

Volume

5

Start / End Page

1231656

Location

Switzerland