Skip to main content
Journal cover image

The relationship of lifetime history of depression on the ovarian tumor immune microenvironment.

Publication ,  Journal Article
Hathaway, CA; Townsend, MK; Conejo-Garcia, JR; Fridley, BL; Moran Segura, C; Nguyen, JV; Armaiz-Pena, GN; Sasamoto, N; Saeed-Vafa, D; Terry, KL ...
Published in: Brain Behav Immun
November 2023

BACKGROUND: Depression is associated with a higher ovarian cancer risk. Prior work suggests that depression can lead to systemic immune suppression, which could potentially alter the anti-tumor immune response. METHODS: We evaluated the association of pre-diagnosis depression with features of the anti-tumor immune response, including T and B cells and immunoglobulins, among women with ovarian tumor tissue collected in three studies, the Nurses' Health Study (NHS; n = 237), NHSII (n = 137) and New England Case-Control Study (NECC; n = 215). Women reporting depressive symptoms above a clinically relevant cut-point, antidepressant use, or physician diagnosis of depression at any time prior to diagnosis of ovarian cancer were considered to have pre-diagnosis depression. Multiplex immunofluorescence was performed on tumor tissue microarrays to measure immune cell infiltration. In pooled analyses, we estimated odds ratios (OR) and 95% confidence intervals (CI) for the positivity of tumor immune cells using a beta-binomial model comparing those with and without depression. We used Bonferroni corrections to adjust for multiple comparisons. RESULTS: We observed no statistically significant association between depression status and any immune markers at the Bonferroni corrected p-value of 0.0045; however, several immune markers were significant at a nominal p-value of 0.05. Specifically, there were increased odds of having recently activated cytotoxic (CD3+CD8+CD69+) and exhausted-like T cells (CD3+Lag3+) in tumors of women with vs. without depression (OR = 1.36, 95 %CI = 1.09-1.69 and OR = 1.24, 95 %CI = 1.01-1.53, respectively). Associations were comparable when considering high grade serous tumors only (comparable ORs = 1.33, 95 %CI = 1.05-1.69 and OR = 1.25, 95 %CI = 0.99-1.58, respectively). There were decreased odds of having tumor infiltrating plasma cells (CD138+) in women with vs. without depression (OR = 0.54, 95 %CI = 0.33-0.90), which was similar among high grade serous carcinomas, although not statistically significant. Depression was also related to decreased odds of having naïve and memory B cells (CD20+: OR = 0.54, 95 %CI = 0.30-0.98) and increased odds of IgG (OR = 1.22, 95 %CI = 0.97-1.53) in high grade serous carcinomas. CONCLUSION: Our results provide suggestive evidence that depression may influence ovarian cancer outcomes through changes in the tumor immune microenvironment, including increasing T cell activation and exhaustion and reducing antibody-producing B cells. Further studies with clinical measures of depression and larger samples are needed to confirm these results.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Brain Behav Immun

DOI

EISSN

1090-2139

Publication Date

November 2023

Volume

114

Start / End Page

52 / 60

Location

Netherlands

Related Subject Headings

  • Tumor Microenvironment
  • Ovarian Neoplasms
  • Neurology & Neurosurgery
  • Humans
  • Female
  • Depression
  • Case-Control Studies
  • Carcinoma
  • Biomarkers
  • 5202 Biological psychology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hathaway, C. A., Townsend, M. K., Conejo-Garcia, J. R., Fridley, B. L., Moran Segura, C., Nguyen, J. V., … Tworoger, S. S. (2023). The relationship of lifetime history of depression on the ovarian tumor immune microenvironment. Brain Behav Immun, 114, 52–60. https://doi.org/10.1016/j.bbi.2023.08.006
Hathaway, Cassandra A., Mary K. Townsend, Jose R. Conejo-Garcia, Brooke L. Fridley, Carlos Moran Segura, Jonathan V. Nguyen, Guillermo N. Armaiz-Pena, et al. “The relationship of lifetime history of depression on the ovarian tumor immune microenvironment.Brain Behav Immun 114 (November 2023): 52–60. https://doi.org/10.1016/j.bbi.2023.08.006.
Hathaway CA, Townsend MK, Conejo-Garcia JR, Fridley BL, Moran Segura C, Nguyen JV, et al. The relationship of lifetime history of depression on the ovarian tumor immune microenvironment. Brain Behav Immun. 2023 Nov;114:52–60.
Hathaway, Cassandra A., et al. “The relationship of lifetime history of depression on the ovarian tumor immune microenvironment.Brain Behav Immun, vol. 114, Nov. 2023, pp. 52–60. Pubmed, doi:10.1016/j.bbi.2023.08.006.
Hathaway CA, Townsend MK, Conejo-Garcia JR, Fridley BL, Moran Segura C, Nguyen JV, Armaiz-Pena GN, Sasamoto N, Saeed-Vafa D, Terry KL, Kubzansky LD, Tworoger SS. The relationship of lifetime history of depression on the ovarian tumor immune microenvironment. Brain Behav Immun. 2023 Nov;114:52–60.
Journal cover image

Published In

Brain Behav Immun

DOI

EISSN

1090-2139

Publication Date

November 2023

Volume

114

Start / End Page

52 / 60

Location

Netherlands

Related Subject Headings

  • Tumor Microenvironment
  • Ovarian Neoplasms
  • Neurology & Neurosurgery
  • Humans
  • Female
  • Depression
  • Case-Control Studies
  • Carcinoma
  • Biomarkers
  • 5202 Biological psychology