Skip to main content

Feasibility of a breath test for monitoring adherence to vaginal administration of antiretroviral microbicide gels.

Publication ,  Journal Article
Morey, TE; Wasdo, S; Wishin, J; Quinn, B; van der Straten, A; Booth, M; Gonzalez, D; Derendorf, H; Melker, RJ; Dennis, DM
Published in: J Clin Pharmacol
January 2013

Adherence to microbicide gel use is critical to optimizing effectiveness in preventing human immunodeficiency virus transmission. The authors hypothesized that ester taggants added to vaginal gels would generate exhaled alcohol and ketone metabolites and provide a "breath test" for vaginal gel use. This 2-arm (vaginal and dermal), randomized, participant-blinded, pilot study tested this hypothesis. On 8 visits, healthy women (n = 8) received intravaginal taggant (2-butyl acetate, 2-pentyl acetate, isopropyl butyrate, or 2-pentyl butyrate; 30 mg) formulated in hydroxyethylcellulose or tenofovir placebo gel. A second group (n = 4) of women received the same formulations administered dermally on the forearm to determine if skin administration might confound the system. Breath samples were collected using bags before and after taggant administration for 1 hour. Samples were measured using a miniature gas chromatograph and/or gas chromatography-mass spectroscopy for ester taggant, alcohol, and ketone concentrations. After vaginal administration, 2-butyl acetate, 2-pentyl acetate, and metabolites were observed in breath, whereas isopropyl butyrate, 2-pentyl butyrate, and metabolites were not. Some women reported self-resolving, mild burning (24/64 visits) with vaginal administration or a "bubblegum" taste (7/64 visits). No taggants or metabolites were detected following dermal application. A "breath test" for adherence to antiretroviral vaginal gel application appears physiologically and technically feasible.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

J Clin Pharmacol

DOI

EISSN

1552-4604

Publication Date

January 2013

Volume

53

Issue

1

Start / End Page

103 / 111

Location

England

Related Subject Headings

  • Young Adult
  • Vaginal Creams, Foams, and Jellies
  • Tenofovir
  • Pharmacology & Pharmacy
  • Patient Compliance
  • Organophosphonates
  • Middle Aged
  • Humans
  • Female
  • Drug Monitoring
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Morey, T. E., Wasdo, S., Wishin, J., Quinn, B., van der Straten, A., Booth, M., … Dennis, D. M. (2013). Feasibility of a breath test for monitoring adherence to vaginal administration of antiretroviral microbicide gels. J Clin Pharmacol, 53(1), 103–111. https://doi.org/10.1177/0091270011434157
Morey, Timothy E., Scott Wasdo, Judith Wishin, Brian Quinn, Ariane van der Straten, Matthew Booth, Daniel Gonzalez, Hartmut Derendorf, Richard J. Melker, and Donn M. Dennis. “Feasibility of a breath test for monitoring adherence to vaginal administration of antiretroviral microbicide gels.J Clin Pharmacol 53, no. 1 (January 2013): 103–11. https://doi.org/10.1177/0091270011434157.
Morey TE, Wasdo S, Wishin J, Quinn B, van der Straten A, Booth M, et al. Feasibility of a breath test for monitoring adherence to vaginal administration of antiretroviral microbicide gels. J Clin Pharmacol. 2013 Jan;53(1):103–11.
Morey, Timothy E., et al. “Feasibility of a breath test for monitoring adherence to vaginal administration of antiretroviral microbicide gels.J Clin Pharmacol, vol. 53, no. 1, Jan. 2013, pp. 103–11. Pubmed, doi:10.1177/0091270011434157.
Morey TE, Wasdo S, Wishin J, Quinn B, van der Straten A, Booth M, Gonzalez D, Derendorf H, Melker RJ, Dennis DM. Feasibility of a breath test for monitoring adherence to vaginal administration of antiretroviral microbicide gels. J Clin Pharmacol. 2013 Jan;53(1):103–111.

Published In

J Clin Pharmacol

DOI

EISSN

1552-4604

Publication Date

January 2013

Volume

53

Issue

1

Start / End Page

103 / 111

Location

England

Related Subject Headings

  • Young Adult
  • Vaginal Creams, Foams, and Jellies
  • Tenofovir
  • Pharmacology & Pharmacy
  • Patient Compliance
  • Organophosphonates
  • Middle Aged
  • Humans
  • Female
  • Drug Monitoring