Role of drug absorption in the pharmacokinetics of therapeutic interventions for stroke.
Publication
, Journal Article
Conrado, DJ; Gonzalez, D; Derendorf, H
Published in: Ann N Y Acad Sci
October 2010
Absorption is a critical component of the pharmacokinetics for solid dosage forms administered orally. Many barriers must be overcome in order for a drug molecule to reach its effect site. To effectively address each of these barriers, drug-specific properties, formulation issues, and (patho)physiological changes in the gastrointestinal tract must be considered. First-pass metabolism in the gut and/or liver can dictate the extent to which a drug reaches the systemic circulation. Drug-metabolizing enzymes in the gut and liver are very susceptible to inhibition by other drugs, increasing the risk of drug interactions. In this paper, we will discuss absorption-related issues for solid dosage forms used in the management of stroke patients.
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Published In
Ann N Y Acad Sci
DOI
EISSN
1749-6632
Publication Date
October 2010
Volume
1207
Start / End Page
134 / 142
Location
United States
Related Subject Headings
- Warfarin
- Ticlopidine
- Stroke
- Platelet Aggregation Inhibitors
- Intestinal Absorption
- Humans
- General Science & Technology
- Dipyridamole
- Clopidogrel
- Anticoagulants
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ICMJE
MLA
NLM
Conrado, D. J., Gonzalez, D., & Derendorf, H. (2010). Role of drug absorption in the pharmacokinetics of therapeutic interventions for stroke. Ann N Y Acad Sci, 1207, 134–142. https://doi.org/10.1111/j.1749-6632.2010.05729.x
Conrado, Daniela J., Daniel Gonzalez, and Hartmut Derendorf. “Role of drug absorption in the pharmacokinetics of therapeutic interventions for stroke.” Ann N Y Acad Sci 1207 (October 2010): 134–42. https://doi.org/10.1111/j.1749-6632.2010.05729.x.
Conrado DJ, Gonzalez D, Derendorf H. Role of drug absorption in the pharmacokinetics of therapeutic interventions for stroke. Ann N Y Acad Sci. 2010 Oct;1207:134–42.
Conrado, Daniela J., et al. “Role of drug absorption in the pharmacokinetics of therapeutic interventions for stroke.” Ann N Y Acad Sci, vol. 1207, Oct. 2010, pp. 134–42. Pubmed, doi:10.1111/j.1749-6632.2010.05729.x.
Conrado DJ, Gonzalez D, Derendorf H. Role of drug absorption in the pharmacokinetics of therapeutic interventions for stroke. Ann N Y Acad Sci. 2010 Oct;1207:134–142.
Published In
Ann N Y Acad Sci
DOI
EISSN
1749-6632
Publication Date
October 2010
Volume
1207
Start / End Page
134 / 142
Location
United States
Related Subject Headings
- Warfarin
- Ticlopidine
- Stroke
- Platelet Aggregation Inhibitors
- Intestinal Absorption
- Humans
- General Science & Technology
- Dipyridamole
- Clopidogrel
- Anticoagulants