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Targeting dorsal root ganglia and primary sensory neurons for the treatment of chronic pain: an update.

Publication ,  Journal Article
Berta, T; Strong, JA; Zhang, J-M; Ji, R-R
Published in: Expert Opin Ther Targets
2023

INTRODUCTION: Current treatments for chronic pain are inadequate. Here, we provide an update on the new therapeutic strategies that target dorsal root ganglia (DRGs) in the peripheral nervous system for a better and safer treatment of chronic pain. AREAS COVERED: Despite the complex nature of chronic pain and its underlying mechanisms, we do know that changes in the plasticity and modality of neurons in DRGs play a pivotal role. DRG neurons are heterogenous and offer potential pain targets for different therapeutic interventions. We discuss the last advancements of these interventions, which include the use of systemic and local administrations, selective nerve drug delivery, and gene therapy. In particular, we provide updates and further details on the molecular characterization of primary sensory neurons, new analgesics entering the market, and future gene therapy approaches. EXPERT OPINION: DRGs and primary sensory neurons are promising targets for chronic pain treatment due to their key role in pain signaling, unique anatomical location, and the potential for different targeted therapeutic interventions.

Duke Scholars

Published In

Expert Opin Ther Targets

DOI

EISSN

1744-7631

Publication Date

2023

Volume

27

Issue

8

Start / End Page

665 / 678

Location

England

Related Subject Headings

  • Sensory Receptor Cells
  • Oncology & Carcinogenesis
  • Humans
  • Ganglia, Spinal
  • Chronic Pain
  • Analgesics
  • 3214 Pharmacology and pharmaceutical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences
  • 0801 Artificial Intelligence and Image Processing
 

Citation

APA
Chicago
ICMJE
MLA
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Berta, T., Strong, J. A., Zhang, J.-M., & Ji, R.-R. (2023). Targeting dorsal root ganglia and primary sensory neurons for the treatment of chronic pain: an update. Expert Opin Ther Targets, 27(8), 665–678. https://doi.org/10.1080/14728222.2023.2247563
Berta, Temugin, Judith A. Strong, Jun-Ming Zhang, and Ru-Rong Ji. “Targeting dorsal root ganglia and primary sensory neurons for the treatment of chronic pain: an update.Expert Opin Ther Targets 27, no. 8 (2023): 665–78. https://doi.org/10.1080/14728222.2023.2247563.
Berta T, Strong JA, Zhang J-M, Ji R-R. Targeting dorsal root ganglia and primary sensory neurons for the treatment of chronic pain: an update. Expert Opin Ther Targets. 2023;27(8):665–78.
Berta, Temugin, et al. “Targeting dorsal root ganglia and primary sensory neurons for the treatment of chronic pain: an update.Expert Opin Ther Targets, vol. 27, no. 8, 2023, pp. 665–78. Pubmed, doi:10.1080/14728222.2023.2247563.
Berta T, Strong JA, Zhang J-M, Ji R-R. Targeting dorsal root ganglia and primary sensory neurons for the treatment of chronic pain: an update. Expert Opin Ther Targets. 2023;27(8):665–678.

Published In

Expert Opin Ther Targets

DOI

EISSN

1744-7631

Publication Date

2023

Volume

27

Issue

8

Start / End Page

665 / 678

Location

England

Related Subject Headings

  • Sensory Receptor Cells
  • Oncology & Carcinogenesis
  • Humans
  • Ganglia, Spinal
  • Chronic Pain
  • Analgesics
  • 3214 Pharmacology and pharmaceutical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences
  • 0801 Artificial Intelligence and Image Processing