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Vortex-ultrasound for microbubble-mediated thrombolysis of retracted clots.

Publication ,  Journal Article
Kim, H; Zhang, B; Wu, H; Yao, J; Shi, C; Jiang, X
Published in: Applied physics letters
August 2023

Endovascular sonothrombolysis has gained significant attention due to its benefits, including direct targeting of the thrombus with sonication and reduced side effects. However, the small aperture of endovascular transducers restricts the improvement of their potential clinical efficiency due to inefficient acoustic radiation. Hence, in an earlier study, we used vortex ultrasound with an endovascular ultrasound transducer to induce shear stress and enhance the clot lysis. In this study, the vortex acoustic transduction mechanism was investigated using numerical simulations and hydrophone tests. Following this characterization, we demonstrated the performance of the vortex ultrasound transducer in thrombolysis of retracted clots in in vitro tests. The test results indicated that the maximum lysis rates were 79.0% and 32.2% with the vortex ultrasound for unretracted and retracted clots, respectively. The vortex ultrasound enhanced the efficiency of the thrombolysis by approximately 49%, both for retracted and unretracted clots, compared with the typical non-vortex ultrasound technique. Therefore, the use of endovascular vortex ultrasound holds promise as a potential clinical option for the thrombolysis of retracted clots.

Duke Scholars

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Published In

Applied physics letters

DOI

EISSN

1077-3118

ISSN

0003-6951

Publication Date

August 2023

Volume

123

Issue

7

Start / End Page

073701

Related Subject Headings

  • Applied Physics
  • 51 Physical sciences
  • 40 Engineering
  • 10 Technology
  • 09 Engineering
  • 02 Physical Sciences
 

Citation

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Kim, H., Zhang, B., Wu, H., Yao, J., Shi, C., & Jiang, X. (2023). Vortex-ultrasound for microbubble-mediated thrombolysis of retracted clots. Applied Physics Letters, 123(7), 073701. https://doi.org/10.1063/5.0155223
Kim, Howuk, Bohua Zhang, Huaiyu Wu, Junjie Yao, Chengzhi Shi, and Xiaoning Jiang. “Vortex-ultrasound for microbubble-mediated thrombolysis of retracted clots.Applied Physics Letters 123, no. 7 (August 2023): 073701. https://doi.org/10.1063/5.0155223.
Kim H, Zhang B, Wu H, Yao J, Shi C, Jiang X. Vortex-ultrasound for microbubble-mediated thrombolysis of retracted clots. Applied physics letters. 2023 Aug;123(7):073701.
Kim, Howuk, et al. “Vortex-ultrasound for microbubble-mediated thrombolysis of retracted clots.Applied Physics Letters, vol. 123, no. 7, Aug. 2023, p. 073701. Epmc, doi:10.1063/5.0155223.
Kim H, Zhang B, Wu H, Yao J, Shi C, Jiang X. Vortex-ultrasound for microbubble-mediated thrombolysis of retracted clots. Applied physics letters. 2023 Aug;123(7):073701.

Published In

Applied physics letters

DOI

EISSN

1077-3118

ISSN

0003-6951

Publication Date

August 2023

Volume

123

Issue

7

Start / End Page

073701

Related Subject Headings

  • Applied Physics
  • 51 Physical sciences
  • 40 Engineering
  • 10 Technology
  • 09 Engineering
  • 02 Physical Sciences