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Risk of Bleeding Among Cangrelor-Treated Patients Administered Upstream P2Y12 Inhibitor Therapy: The CAMEO Registry

Publication ,  Conference
Rymer, J; Alhanti, B; Kemp, S; Bhatt, DL; Kochar, A; Angiolillo, DJ; Diaz, M; Garratt, KN; Wimmer, NJ; Waksman, R; Kirtane, AJ; Ang, L ...
Published in: Journal of the Society for Cardiovascular Angiography and Interventions
February 1, 2024

Background: Little is known about the bleeding risk associated with cangrelor use in patients with myocardial infarction (MI) who are exposed to an oral P2Y12 inhibitor before coronary angiography. Methods: Cangrelor in Acute MI: Effectiveness and Outcomes (CAMEO) is an observational registry studying platelet inhibition for patients with MI. Upstream oral P2Y12 inhibition was defined as receipt of an oral P2Y12 inhibitor within 24 hours before hospitalization or in-hospital before angiography. Among cangrelor-treated patients, we compared bleeding after cangrelor use through 7 days postdischarge between patients with and without upstream oral P2Y12 inhibitor exposure. Results: Among 1802 cangrelor-treated patients with MI, 385 (21.4%) received upstream oral P2Y12 inhibitor treatment. Of these, 101 patients (33.8%) started cangrelor within 1 hour, 103 (34.4%) between 1 and 3 hours, and 95 (31.8%), >3 hours after in-hospital oral P2Y12 inhibitor administration; the remaining received an oral P2Y12 inhibitor before hospitalization. There was no statistically significant difference in rates of bleeding among cangrelor-treated patients with and without upstream oral P2Y12 inhibitor exposure (6.5% vs 8.8%; adjusted odds ratio [OR], 0.62; 95% CI, 0.38-1.01). Bleeding was observed in 5.0%, 10.7%, and 3.2% of patients treated with cangrelor <1, 1 to 3, and >3 hours after the last oral PY12 inhibitor dose, respectively; bleeding rates were not statistically different between groups (1-3 hours vs <1 hour: adjusted OR, 2.70; 95% CI, 0.87-8.32; >3 hours vs <1 hour: adjusted OR, 0.65; 95% CI, 0.15-2.85). Conclusions: Bleeding risk was not observed to be significantly higher after cangrelor treatment in patients with and without upstream oral P2Y12 inhibitor exposure.

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Published In

Journal of the Society for Cardiovascular Angiography and Interventions

DOI

EISSN

2772-9303

Publication Date

February 1, 2024

Volume

3

Issue

2
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Rymer, J., Alhanti, B., Kemp, S., Bhatt, D. L., Kochar, A., Angiolillo, D. J., … Wang, T. Y. (2024). Risk of Bleeding Among Cangrelor-Treated Patients Administered Upstream P2Y12 Inhibitor Therapy: The CAMEO Registry. In Journal of the Society for Cardiovascular Angiography and Interventions (Vol. 3). https://doi.org/10.1016/j.jscai.2023.101202
Rymer, J., B. Alhanti, S. Kemp, D. L. Bhatt, A. Kochar, D. J. Angiolillo, M. Diaz, et al. “Risk of Bleeding Among Cangrelor-Treated Patients Administered Upstream P2Y12 Inhibitor Therapy: The CAMEO Registry.” In Journal of the Society for Cardiovascular Angiography and Interventions, Vol. 3, 2024. https://doi.org/10.1016/j.jscai.2023.101202.
Rymer J, Alhanti B, Kemp S, Bhatt DL, Kochar A, Angiolillo DJ, et al. Risk of Bleeding Among Cangrelor-Treated Patients Administered Upstream P2Y12 Inhibitor Therapy: The CAMEO Registry. In: Journal of the Society for Cardiovascular Angiography and Interventions. 2024.
Rymer, J., et al. “Risk of Bleeding Among Cangrelor-Treated Patients Administered Upstream P2Y12 Inhibitor Therapy: The CAMEO Registry.” Journal of the Society for Cardiovascular Angiography and Interventions, vol. 3, no. 2, 2024. Scopus, doi:10.1016/j.jscai.2023.101202.
Rymer J, Alhanti B, Kemp S, Bhatt DL, Kochar A, Angiolillo DJ, Diaz M, Garratt KN, Wimmer NJ, Waksman R, Kirtane AJ, Ang L, Bach R, Barker C, Jenkins R, Basir MB, Sullivan A, El-Sabae H, Brothers L, Ohman EM, Jones WS, Washam JB, Wang TY. Risk of Bleeding Among Cangrelor-Treated Patients Administered Upstream P2Y12 Inhibitor Therapy: The CAMEO Registry. Journal of the Society for Cardiovascular Angiography and Interventions. 2024.

Published In

Journal of the Society for Cardiovascular Angiography and Interventions

DOI

EISSN

2772-9303

Publication Date

February 1, 2024

Volume

3

Issue

2