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Retained Biopsy Site Markers After Breast Lesion Surgical Resection: Associations With Residual Malignancy.

Publication ,  Journal Article
Langman, EL; Johnson, KS; Dinome, ML
Published in: AJR Am J Roentgenol
January 2024

BACKGROUND. Biopsy site markers (BSMs) placed during image-guided core needle biopsy (CNB) are typically targeted for surgical excision, along with the breast imaging abnormality. Retained BSMs raise concern of incomplete resection of the breast abnormality. OBJECTIVE. The purpose of our study was to assess the frequency of residual malignancy in patients with retained BSMs identified on the initial mammography performed after breast lesion surgical excision. METHODS. This retrospective study included 30 patients (median age, 59 years) who underwent surgical resection between August 2015 and April 2022 of a borderline, high-risk, or malignant breast lesion after CNB and technically adequate preoperative image-guided localization, in whom the initial postoperative mammography report described a retained nonmigrated BSM. EMR data were extracted. The index pathology from CNB and initial surgical resection was classified as malignant or nonmalignant. The presence of residual malignancy after initial surgical resection required pathologic confirmation from subsequent tissue sampling; the absence of residual malignancy required 2 years of benign imaging follow-up. RESULTS. Thirteen specimen radiographs were interpreted intraoperatively by a surgeon with later radiologist interpretation, and 17 underwent real-time radiologist interpretation. Eighteen patients had malignant index pathology from the initially resected lesion. The frequency of residual malignancy on subsequent follow-up after initial surgical resection was higher in patients with malignant than nonmalignant index pathology (39% [7/18] vs 0% [0/12], respectively; p = .02). Among patients with malignant index pathology, the frequency of residual malignancy was higher in those without, than with, malignancy in the initial surgical specimen (80% [4/5] vs 23% [3/13]; p = .047). Also in these patients, the frequency of a positive interpretation of the initial postoperative mammography (BI-RADS category 4 or 6) was not significantly different between those with and without residual malignancy (57% [4/7] vs 55% [6/11]; p > .99). CONCLUSION. Patients with retained BSMs associated with malignant index lesions are at substantial risk of having residual malignancy. Initial postoperative mammography is not sufficient for excluding residual malignancy. CLINICAL IMPACT. Retained BSMs associated with index malignancy should be considered suspicious for residual malignancy. In this scenario, timely additional tissue sampling targeting the retained BSM is warranted, given the greater-than-2% chance of malignancy. Active surveillance is a reasonable management strategy in patients with retained BSMs from nonmalignant index lesions.

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Published In

AJR Am J Roentgenol

DOI

EISSN

1546-3141

Publication Date

January 2024

Volume

222

Issue

1

Start / End Page

e2329670

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Nuclear Medicine & Medical Imaging
  • Neoplasm, Residual
  • Middle Aged
  • Mammography
  • Image-Guided Biopsy
  • Humans
  • Female
  • Breast Neoplasms
  • Breast Diseases
 

Citation

APA
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ICMJE
MLA
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Langman, E. L., Johnson, K. S., & Dinome, M. L. (2024). Retained Biopsy Site Markers After Breast Lesion Surgical Resection: Associations With Residual Malignancy. AJR Am J Roentgenol, 222(1), e2329670. https://doi.org/10.2214/AJR.23.29670
Langman, Eun L., Karen S. Johnson, and Maggie L. Dinome. “Retained Biopsy Site Markers After Breast Lesion Surgical Resection: Associations With Residual Malignancy.AJR Am J Roentgenol 222, no. 1 (January 2024): e2329670. https://doi.org/10.2214/AJR.23.29670.
Langman EL, Johnson KS, Dinome ML. Retained Biopsy Site Markers After Breast Lesion Surgical Resection: Associations With Residual Malignancy. AJR Am J Roentgenol. 2024 Jan;222(1):e2329670.
Langman, Eun L., et al. “Retained Biopsy Site Markers After Breast Lesion Surgical Resection: Associations With Residual Malignancy.AJR Am J Roentgenol, vol. 222, no. 1, Jan. 2024, p. e2329670. Pubmed, doi:10.2214/AJR.23.29670.
Langman EL, Johnson KS, Dinome ML. Retained Biopsy Site Markers After Breast Lesion Surgical Resection: Associations With Residual Malignancy. AJR Am J Roentgenol. 2024 Jan;222(1):e2329670.

Published In

AJR Am J Roentgenol

DOI

EISSN

1546-3141

Publication Date

January 2024

Volume

222

Issue

1

Start / End Page

e2329670

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Nuclear Medicine & Medical Imaging
  • Neoplasm, Residual
  • Middle Aged
  • Mammography
  • Image-Guided Biopsy
  • Humans
  • Female
  • Breast Neoplasms
  • Breast Diseases