
HIV specific Th1 responses are altered in Ugandans with HIV and Schistosoma mansoni coinfection.
BACKGROUND: Fishing communities surrounding Lake Victoria in Uganda have HIV prevalence of 28% and incidence rates of 5 per 100 person years. More than 50% of the local fishermen are infected with Schistosoma mansoni (S. mansoni). We investigated the role of S. mansoni coinfection as a possible modifier of immune responses against HIV. Using polychromatic flow cytometry and Gran-ToxiLux assays, HIV specific responses, T cell phenotypes, antibody-dependent cell-mediated cytotoxic (ADCC) potency and titres were compared between participants with HIV-S. mansoni coinfection and participants with HIV infection alone. RESULTS: S. mansoni coinfection was associated with a modified pattern of anti-HIV responses, including lower frequency of bifunctional (IFNγ + IL-2 - TNF-α+) CD4 T cells, higher overall CD4 T cell activation and lower HIV ADCC antibody titres, compared to participants with HIV alone. CONCLUSIONS: These results support the hypothesis that S. mansoni infection affects T cell and antibody responses to HIV in coinfected individuals.
Duke Scholars
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Related Subject Headings
- Schistosomiasis
- Schistosoma mansoni
- Immunology
- HIV Infections
- East African People
- Coinfection
- Antibodies
- Animals
- 3204 Immunology
- 1107 Immunology
Citation

Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Schistosomiasis
- Schistosoma mansoni
- Immunology
- HIV Infections
- East African People
- Coinfection
- Antibodies
- Animals
- 3204 Immunology
- 1107 Immunology