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HIV specific Th1 responses are altered in Ugandans with HIV and Schistosoma mansoni coinfection.

Publication ,  Journal Article
Obuku, AE; Lugemwa, JK; Abaasa, A; Joloba, M; Ding, S; Pollara, J; Ferrari, G; Harari, A; Pantaleo, G; Kaleebu, P
Published in: BMC Immunol
August 29, 2023

BACKGROUND: Fishing communities surrounding Lake Victoria in Uganda have HIV prevalence of 28% and incidence rates of 5 per 100 person years. More than 50% of the local fishermen are infected with Schistosoma mansoni (S. mansoni). We investigated the role of S. mansoni coinfection as a possible modifier of immune responses against HIV. Using polychromatic flow cytometry and Gran-ToxiLux assays, HIV specific responses, T cell phenotypes, antibody-dependent cell-mediated cytotoxic (ADCC) potency and titres were compared between participants with HIV-S. mansoni coinfection and participants with HIV infection alone. RESULTS: S. mansoni coinfection was associated with a modified pattern of anti-HIV responses, including lower frequency of bifunctional (IFNγ + IL-2 - TNF-α+) CD4 T cells, higher overall CD4 T cell activation and lower HIV ADCC antibody titres, compared to participants with HIV alone. CONCLUSIONS: These results support the hypothesis that S. mansoni infection affects T cell and antibody responses to HIV in coinfected individuals.

Duke Scholars

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Published In

BMC Immunol

DOI

EISSN

1471-2172

Publication Date

August 29, 2023

Volume

24

Issue

1

Start / End Page

25

Location

England

Related Subject Headings

  • Schistosomiasis
  • Schistosoma mansoni
  • Immunology
  • HIV Infections
  • East African People
  • Coinfection
  • Antibodies
  • Animals
  • 3204 Immunology
  • 1107 Immunology
 

Citation

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Chicago
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Obuku, A. E., Lugemwa, J. K., Abaasa, A., Joloba, M., Ding, S., Pollara, J., … Kaleebu, P. (2023). HIV specific Th1 responses are altered in Ugandans with HIV and Schistosoma mansoni coinfection. BMC Immunol, 24(1), 25. https://doi.org/10.1186/s12865-023-00554-3
Obuku, Andrew Ekii, Jacqueline Kyosiimire Lugemwa, Andrew Abaasa, Moses Joloba, Song Ding, Justin Pollara, Guido Ferrari, Alexandre Harari, Giuseppe Pantaleo, and Pontiano Kaleebu. “HIV specific Th1 responses are altered in Ugandans with HIV and Schistosoma mansoni coinfection.BMC Immunol 24, no. 1 (August 29, 2023): 25. https://doi.org/10.1186/s12865-023-00554-3.
Obuku AE, Lugemwa JK, Abaasa A, Joloba M, Ding S, Pollara J, et al. HIV specific Th1 responses are altered in Ugandans with HIV and Schistosoma mansoni coinfection. BMC Immunol. 2023 Aug 29;24(1):25.
Obuku, Andrew Ekii, et al. “HIV specific Th1 responses are altered in Ugandans with HIV and Schistosoma mansoni coinfection.BMC Immunol, vol. 24, no. 1, Aug. 2023, p. 25. Pubmed, doi:10.1186/s12865-023-00554-3.
Obuku AE, Lugemwa JK, Abaasa A, Joloba M, Ding S, Pollara J, Ferrari G, Harari A, Pantaleo G, Kaleebu P. HIV specific Th1 responses are altered in Ugandans with HIV and Schistosoma mansoni coinfection. BMC Immunol. 2023 Aug 29;24(1):25.
Journal cover image

Published In

BMC Immunol

DOI

EISSN

1471-2172

Publication Date

August 29, 2023

Volume

24

Issue

1

Start / End Page

25

Location

England

Related Subject Headings

  • Schistosomiasis
  • Schistosoma mansoni
  • Immunology
  • HIV Infections
  • East African People
  • Coinfection
  • Antibodies
  • Animals
  • 3204 Immunology
  • 1107 Immunology