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Characterizing the Contribution of Indoor Residential Phthalate and Phthalate Alternative Dust Concentrations to Internal Dose in the US General Population: An Updated Systematic Review and Meta-Analysis.

Publication ,  Journal Article
Milton, SG; Tejiram, RA; Joglekar, R; Hoffman, K
Published in: International journal of environmental research and public health
August 2023

Diet is the primary exposure pathway for phthalates, but relative contributions of other exposure sources are not well characterized. This study quantifies the relative contribution of indoor residential dust phthalate and phthalate alternative concentrations to total internal dose estimated from the National Health and Nutrition Examination Survey (NHANES) urinary metabolite concentrations. Specifically, median phthalate and phthalate alternative concentrations measured in residential dust were determined by updating a pre-existing systematic review and meta-analysis published in 2015 and the attributable internal dose was estimated using intake and reverse dosimetry models. Employing a predetermined search strategy, 12 studies published between January 2000 and April 2022 from Web of Science and PubMed measuring phthalates and phthalate alternatives in residential dust were identified. From the data extracted, it was estimated that dust contributed more significantly to the internal dose of low-molecular weight chemicals such as DEP and BBP when compared to high-molecular weight chemicals such as DEHTP. Additionally, findings showed that the chemical profile of residential dust is changing temporally with more phthalate alternatives being detected in the indoor environment. Future studies should seek to characterize the contribution of dust to an overall phthalate and phthalate alternative intake for individuals who have higher than normal exposures.

Duke Scholars

Published In

International journal of environmental research and public health

DOI

EISSN

1660-4601

ISSN

1661-7827

Publication Date

August 2023

Volume

20

Issue

16

Start / End Page

6589

Related Subject Headings

  • Toxicology
  • Thinness
  • Phthalic Acids
  • Nutrition Surveys
  • Molecular Weight
  • Humans
  • Dust
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Milton, S. G., Tejiram, R. A., Joglekar, R., & Hoffman, K. (2023). Characterizing the Contribution of Indoor Residential Phthalate and Phthalate Alternative Dust Concentrations to Internal Dose in the US General Population: An Updated Systematic Review and Meta-Analysis. International Journal of Environmental Research and Public Health, 20(16), 6589. https://doi.org/10.3390/ijerph20166589
Milton, Sashoy G., Rachel A. Tejiram, Rashmi Joglekar, and Kate Hoffman. “Characterizing the Contribution of Indoor Residential Phthalate and Phthalate Alternative Dust Concentrations to Internal Dose in the US General Population: An Updated Systematic Review and Meta-Analysis.International Journal of Environmental Research and Public Health 20, no. 16 (August 2023): 6589. https://doi.org/10.3390/ijerph20166589.
Milton, Sashoy G., et al. “Characterizing the Contribution of Indoor Residential Phthalate and Phthalate Alternative Dust Concentrations to Internal Dose in the US General Population: An Updated Systematic Review and Meta-Analysis.International Journal of Environmental Research and Public Health, vol. 20, no. 16, Aug. 2023, p. 6589. Epmc, doi:10.3390/ijerph20166589.

Published In

International journal of environmental research and public health

DOI

EISSN

1660-4601

ISSN

1661-7827

Publication Date

August 2023

Volume

20

Issue

16

Start / End Page

6589

Related Subject Headings

  • Toxicology
  • Thinness
  • Phthalic Acids
  • Nutrition Surveys
  • Molecular Weight
  • Humans
  • Dust