Daphnepedunins G and H, anti-HIV macrocyclic 3,4-seco-daphnane orthoesters from Daphne pedunculata.
Publication
, Journal Article
Tan, L; Otsuki, K; Zhang, M; Kikuchi, T; Zhou, D; Li, N; Huang, L; Chen, C-H; Li, W
Published in: J Nat Med
January 2024
Daphnepedunins G (1) and H (2) with unusual macrocyclic 3,4-seco-daphnane orthoester structure were isolated from Daphne pedunculata. Their structures were determined by physicochemical and spectroscopic analyses combined with synthetic methods, including methyl esterification, derivatization reaction using a chiral anisotropic agent, and biomimetic conversion. Compounds 1 and 2 along with their methyl esters 1a and 2a were evaluated for anti-HIV activity, among which 1a and 2a exhibited potent activity with IC50 values of 1.08 and 1.17 μM, respectively.
Duke Scholars
Published In
J Nat Med
DOI
EISSN
1861-0293
Publication Date
January 2024
Volume
78
Issue
1
Start / End Page
114 / 122
Location
Japan
Related Subject Headings
- Thoracica
- Molecular Structure
- Medicinal & Biomolecular Chemistry
- Diterpenes
- Daphne
- Animals
- 4208 Traditional, complementary and integrative medicine
Citation
APA
Chicago
ICMJE
MLA
NLM
Tan, L., Otsuki, K., Zhang, M., Kikuchi, T., Zhou, D., Li, N., … Li, W. (2024). Daphnepedunins G and H, anti-HIV macrocyclic 3,4-seco-daphnane orthoesters from Daphne pedunculata. J Nat Med, 78(1), 114–122. https://doi.org/10.1007/s11418-023-01750-6
Tan, Lingjian, Kouharu Otsuki, Mi Zhang, Takashi Kikuchi, Di Zhou, Ning Li, Li Huang, Chin-Ho Chen, and Wei Li. “Daphnepedunins G and H, anti-HIV macrocyclic 3,4-seco-daphnane orthoesters from Daphne pedunculata.” J Nat Med 78, no. 1 (January 2024): 114–22. https://doi.org/10.1007/s11418-023-01750-6.
Tan L, Otsuki K, Zhang M, Kikuchi T, Zhou D, Li N, et al. Daphnepedunins G and H, anti-HIV macrocyclic 3,4-seco-daphnane orthoesters from Daphne pedunculata. J Nat Med. 2024 Jan;78(1):114–22.
Tan, Lingjian, et al. “Daphnepedunins G and H, anti-HIV macrocyclic 3,4-seco-daphnane orthoesters from Daphne pedunculata.” J Nat Med, vol. 78, no. 1, Jan. 2024, pp. 114–22. Pubmed, doi:10.1007/s11418-023-01750-6.
Tan L, Otsuki K, Zhang M, Kikuchi T, Zhou D, Li N, Huang L, Chen C-H, Li W. Daphnepedunins G and H, anti-HIV macrocyclic 3,4-seco-daphnane orthoesters from Daphne pedunculata. J Nat Med. 2024 Jan;78(1):114–122.
Published In
J Nat Med
DOI
EISSN
1861-0293
Publication Date
January 2024
Volume
78
Issue
1
Start / End Page
114 / 122
Location
Japan
Related Subject Headings
- Thoracica
- Molecular Structure
- Medicinal & Biomolecular Chemistry
- Diterpenes
- Daphne
- Animals
- 4208 Traditional, complementary and integrative medicine