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Deposition of 11C-radiolabeled nicotine-containing aerosol in an airway cast model using positron emission tomography (PET)

Publication ,  Journal Article
Rose, JE; Kuczaj, AK; Mukhin, AG; Hoeng, J; Sai, KKS
Published in: Aerosol Science and Technology
January 1, 2023

We recently developed an in vitro system for quantification of deposited mass of labeled aerosol constituents in the human airway under realistic inhalation conditions including temperature and humidity control. The in vitro system consists of the upper respiratory airway cast with separate flow controls within distinct branches of the cast. The complete workflow including generation of the labeled aerosol particles, flow setup, and scanning deposited labeled constituent using positron emission tomography is presented. The system was used for evaluating deposition of 11C-radiolabeled nicotine from pH-modified liquid formulations generated by a typical tank electronic nicotine delivery system. The airway deposition patterns were modulated by adjusted liquid pH-value, suggesting modified gas-liquid aerosol partitioning. This can be visually assessed in a qualitative manner, but more importantly measured in a quantitative manner by evaluating the total administered dose. The effects of temperature and humidity were separately assessed, showing significant influence of realistic inhalation conditions (temperature of 37 °C and nearly 100% relative humidity) on total nicotine deposition in the airway cast. Developed capabilities allow their future applications in generating validation data for modeling purposes as well as for conducting further studies concerning understanding of challenges in aerosol delivery and dosimetry assessments.

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Published In

Aerosol Science and Technology

DOI

EISSN

1521-7388

ISSN

0278-6826

Publication Date

January 1, 2023

Volume

57

Issue

11

Start / End Page

1057 / 1068

Related Subject Headings

  • Meteorology & Atmospheric Sciences
  • 40 Engineering
  • 37 Earth sciences
  • 34 Chemical sciences
  • 09 Engineering
  • 04 Earth Sciences
  • 03 Chemical Sciences
 

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Rose, J. E., Kuczaj, A. K., Mukhin, A. G., Hoeng, J., & Sai, K. K. S. (2023). Deposition of 11C-radiolabeled nicotine-containing aerosol in an airway cast model using positron emission tomography (PET). Aerosol Science and Technology, 57(11), 1057–1068. https://doi.org/10.1080/02786826.2023.2242901
Rose, J. E., A. K. Kuczaj, A. G. Mukhin, J. Hoeng, and K. K. S. Sai. “Deposition of 11C-radiolabeled nicotine-containing aerosol in an airway cast model using positron emission tomography (PET).” Aerosol Science and Technology 57, no. 11 (January 1, 2023): 1057–68. https://doi.org/10.1080/02786826.2023.2242901.
Rose JE, Kuczaj AK, Mukhin AG, Hoeng J, Sai KKS. Deposition of 11C-radiolabeled nicotine-containing aerosol in an airway cast model using positron emission tomography (PET). Aerosol Science and Technology. 2023 Jan 1;57(11):1057–68.
Rose, J. E., et al. “Deposition of 11C-radiolabeled nicotine-containing aerosol in an airway cast model using positron emission tomography (PET).” Aerosol Science and Technology, vol. 57, no. 11, Jan. 2023, pp. 1057–68. Scopus, doi:10.1080/02786826.2023.2242901.
Rose JE, Kuczaj AK, Mukhin AG, Hoeng J, Sai KKS. Deposition of 11C-radiolabeled nicotine-containing aerosol in an airway cast model using positron emission tomography (PET). Aerosol Science and Technology. 2023 Jan 1;57(11):1057–1068.

Published In

Aerosol Science and Technology

DOI

EISSN

1521-7388

ISSN

0278-6826

Publication Date

January 1, 2023

Volume

57

Issue

11

Start / End Page

1057 / 1068

Related Subject Headings

  • Meteorology & Atmospheric Sciences
  • 40 Engineering
  • 37 Earth sciences
  • 34 Chemical sciences
  • 09 Engineering
  • 04 Earth Sciences
  • 03 Chemical Sciences