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Exploring the Role of Spatial Confinement in Immune Cell Recruitment and Regeneration of Skin Wounds.

Publication ,  Journal Article
Liu, Y; Suarez-Arnedo, A; Caston, ELP; Riley, L; Schneider, M; Segura, T
Published in: Advanced materials (Deerfield Beach, Fla.)
December 2023

Microporous annealed particle (MAP) scaffolds are injectable granular materials comprised of micron sized hydrogel particles (microgels). The diameter of these microgels directly determines the size of the interconnected void space between particles where infiltrating or encapsulated cells reside. This tunable porosity allows the authors to use MAP scaffolds to study the impact of spatial confinement (SC) on both cellular behaviors and the host response to biomaterials. Despite previous studies showing that pore size and SC influence cellular phenotypes, including mitigating macrophage inflammatory response, there is still a gap in knowledge regarding how SC within a biomaterial modulates immune cell recruitment in vivo in wounds and implants. Thus, the immune cell profile within confined and unconfined biomaterials is studied using small (40 µm), medium (70 µm), and large (130 µm) diameter spherical microgels, respectively. This work uncovered that MAP scaffolds impart regenerative wound healing with an IgG1-biased Th2 response. MAP scaffolds made with large microgels promote a balanced pro-regenerative macrophage response, resulting in enhanced wound healing with mature collagen regeneration and reduced inflammation levels.

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Published In

Advanced materials (Deerfield Beach, Fla.)

DOI

EISSN

1521-4095

ISSN

0935-9648

Publication Date

December 2023

Volume

35

Issue

49

Start / End Page

e2304049

Related Subject Headings

  • Wound Healing
  • Tissue Scaffolds
  • Nanoscience & Nanotechnology
  • Microgels
  • Hydrogels
  • Collagen
  • Biocompatible Materials
  • 51 Physical sciences
  • 40 Engineering
  • 34 Chemical sciences
 

Citation

APA
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ICMJE
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Liu, Y., Suarez-Arnedo, A., Caston, E. L. P., Riley, L., Schneider, M., & Segura, T. (2023). Exploring the Role of Spatial Confinement in Immune Cell Recruitment and Regeneration of Skin Wounds. Advanced Materials (Deerfield Beach, Fla.), 35(49), e2304049. https://doi.org/10.1002/adma.202304049
Liu, Yining, Alejandra Suarez-Arnedo, Eleanor L. P. Caston, Lindsay Riley, Michelle Schneider, and Tatiana Segura. “Exploring the Role of Spatial Confinement in Immune Cell Recruitment and Regeneration of Skin Wounds.Advanced Materials (Deerfield Beach, Fla.) 35, no. 49 (December 2023): e2304049. https://doi.org/10.1002/adma.202304049.
Liu Y, Suarez-Arnedo A, Caston ELP, Riley L, Schneider M, Segura T. Exploring the Role of Spatial Confinement in Immune Cell Recruitment and Regeneration of Skin Wounds. Advanced materials (Deerfield Beach, Fla). 2023 Dec;35(49):e2304049.
Liu, Yining, et al. “Exploring the Role of Spatial Confinement in Immune Cell Recruitment and Regeneration of Skin Wounds.Advanced Materials (Deerfield Beach, Fla.), vol. 35, no. 49, Dec. 2023, p. e2304049. Epmc, doi:10.1002/adma.202304049.
Liu Y, Suarez-Arnedo A, Caston ELP, Riley L, Schneider M, Segura T. Exploring the Role of Spatial Confinement in Immune Cell Recruitment and Regeneration of Skin Wounds. Advanced materials (Deerfield Beach, Fla). 2023 Dec;35(49):e2304049.
Journal cover image

Published In

Advanced materials (Deerfield Beach, Fla.)

DOI

EISSN

1521-4095

ISSN

0935-9648

Publication Date

December 2023

Volume

35

Issue

49

Start / End Page

e2304049

Related Subject Headings

  • Wound Healing
  • Tissue Scaffolds
  • Nanoscience & Nanotechnology
  • Microgels
  • Hydrogels
  • Collagen
  • Biocompatible Materials
  • 51 Physical sciences
  • 40 Engineering
  • 34 Chemical sciences