Mechanisms-Based Pain Therapies
Chronic pain is a prevalent disease with high impact on public health and individual’s quality of life. Understanding the complex mechanisms and causes of pain is crucial for precise diagnosis, adequate management, and better patient outcomes. As we deepen our knowledge, new therapeutic targets and strategies are expanding and becoming more mechanism-based. Current mechanism-based therapies include approaches to modulating the transduction, conduction, transmission, perception, and adaptation of pain through pharmacological, interventional, surgical, physical/psychological behavioral treatments. Increasing evidence suggests that some of these treatments can not only alleviate pain symptoms but also control disease progression by modulation of inflammation and neuroinflammation.
