Neuroimmune Interactions in Pain: Mechanisms and Therapeutics
Inflammatory Mediators, Nociceptors, and Their Interactions in Pain
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Ji, J; Huh, Y; Ji, RR
January 1, 2023
Inflammation produces pro-inflammatory mediators for the induction of pain. These mediators include inflammatory cytokines and chemokines, lipids, and microRNAs. These inflammatory mediators bind respective receptors on nociceptor terminals and cell bodies to trigger nociceptor activation and sensitization (peripheral sensitization). Inflammation also generates anti-inflammatory and pro-resolving mediators (SPMs) for the resolution of acute pain. Notably, specialized pro-mediators (SPMs) such as resolvins produce potent inhibition of inflammation and pain. A failure in SPM production and signaling and resolution of acute pain will lead to acute pain to chronic pain transition.
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Ji, J., Huh, Y., & Ji, R. R. (2023). Inflammatory Mediators, Nociceptors, and Their Interactions in Pain. In Neuroimmune Interactions in Pain: Mechanisms and Therapeutics (pp. 87–119). https://doi.org/10.1007/978-3-031-29231-6_4
Ji, J., Y. Huh, and R. R. Ji. “Inflammatory Mediators, Nociceptors, and Their Interactions in Pain.” In Neuroimmune Interactions in Pain: Mechanisms and Therapeutics, 87–119, 2023. https://doi.org/10.1007/978-3-031-29231-6_4.
Ji J, Huh Y, Ji RR. Inflammatory Mediators, Nociceptors, and Their Interactions in Pain. In: Neuroimmune Interactions in Pain: Mechanisms and Therapeutics. 2023. p. 87–119.
Ji, J., et al. “Inflammatory Mediators, Nociceptors, and Their Interactions in Pain.” Neuroimmune Interactions in Pain: Mechanisms and Therapeutics, 2023, pp. 87–119. Scopus, doi:10.1007/978-3-031-29231-6_4.
Ji J, Huh Y, Ji RR. Inflammatory Mediators, Nociceptors, and Their Interactions in Pain. Neuroimmune Interactions in Pain: Mechanisms and Therapeutics. 2023. p. 87–119.