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Mechanosensing Piezo channels in gastrointestinal disorders.

Publication ,  Journal Article
Swain, SM; Liddle, RA
Published in: J Clin Invest
October 2, 2023

All cells in the body are exposed to physical force in the form of tension, compression, gravity, shear stress, or pressure. Cells convert these mechanical cues into intracellular biochemical signals; this process is an inherent property of all cells and is essential for numerous cellular functions. A cell's ability to respond to force largely depends on the array of mechanical ion channels expressed on the cell surface. Altered mechanosensing impairs conscious senses, such as touch and hearing, and unconscious senses, like blood pressure regulation and gastrointestinal (GI) activity. The GI tract's ability to sense pressure changes and mechanical force is essential for regulating motility, but it also underlies pain originating in the GI tract. Recent identification of the mechanically activated ion channels Piezo1 and Piezo2 in the gut and the effects of abnormal ion channel regulation on cellular function indicate that these channels may play a pathogenic role in disease. Here, we discuss our current understanding of mechanically activated Piezo channels in the pathogenesis of pancreatic and GI diseases, including pancreatitis, diabetes mellitus, irritable bowel syndrome, GI tumors, and inflammatory bowel disease. We also describe how Piezo channels could be important targets for treating GI diseases.

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Published In

J Clin Invest

DOI

EISSN

1558-8238

Publication Date

October 2, 2023

Volume

133

Issue

19

Location

United States

Related Subject Headings

  • Mechanotransduction, Cellular
  • Ion Channels
  • Immunology
  • Humans
  • Gastrointestinal Diseases
  • Cell Membrane
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
  • 11 Medical and Health Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Swain, S. M., & Liddle, R. A. (2023). Mechanosensing Piezo channels in gastrointestinal disorders. J Clin Invest, 133(19). https://doi.org/10.1172/JCI171955
Swain, Sandip M., and Rodger A. Liddle. “Mechanosensing Piezo channels in gastrointestinal disorders.J Clin Invest 133, no. 19 (October 2, 2023). https://doi.org/10.1172/JCI171955.
Swain SM, Liddle RA. Mechanosensing Piezo channels in gastrointestinal disorders. J Clin Invest. 2023 Oct 2;133(19).
Swain, Sandip M., and Rodger A. Liddle. “Mechanosensing Piezo channels in gastrointestinal disorders.J Clin Invest, vol. 133, no. 19, Oct. 2023. Pubmed, doi:10.1172/JCI171955.
Swain SM, Liddle RA. Mechanosensing Piezo channels in gastrointestinal disorders. J Clin Invest. 2023 Oct 2;133(19).

Published In

J Clin Invest

DOI

EISSN

1558-8238

Publication Date

October 2, 2023

Volume

133

Issue

19

Location

United States

Related Subject Headings

  • Mechanotransduction, Cellular
  • Ion Channels
  • Immunology
  • Humans
  • Gastrointestinal Diseases
  • Cell Membrane
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
  • 11 Medical and Health Sciences